腺苷三磷酸 氯化镁对实验性急性呼吸窘迫综合征动脉血氧分压的影响

Effect of ATP magnesium chloride on PaO 2 in experimental acute respiratory distress syndrome

［ 目的］ 研究腺苷三磷酸氯化镁对油酸性急性呼吸窘迫综合征动脉血氧分压的影响．［ 方法］ 以２１ 只大白鼠为实验动物，建立油酸型急性呼吸窘迫综合征模型，随机分为３ 组，即正常组、损伤组及治疗组，观察肺组织病理改变及动脉血氧分压变化．［ 结果］ 腺苷三磷酸氯化镁治疗组的病理改变比损伤组明显减轻，治疗组动脉血氧分压高于损伤组．［ 结论］

OBJECTIVE To investigate effects of ATP magnesium chloride on PaO 2 in experimental acute respiratory distress syndrome.METHOD 21 rats were divided into 3 groups:control group,oleic acid group and ATP magnesium chloride treated group.Acute respiratory distress model was produced by intravenous injection of oleic acid. RESULT PaO 2 in ATP megnesiun chloride treated group was higher than that in oleic acid group.CONCLUSION Histologic injury in ATP magnesium chloride treated group was significantly improved as compared with oleic acid group.