L-香芹酮硫醚类化合物的合成及其对三种植物病原真菌的活性研究

The Chemical Modification of L(-)-Carvone and its Biological Activity to Three Fungal Pathogens of Plant

以香芹酮为原料,经氯代、亲核取代合成了6个香芹酮硫醚类化合物,其结构经过了1HNMR、IR和元素分析的确证。对其初步生物活性测试结果表明:部分化合物对水稻稻瘟病菌、小麦赤霉病菌、辣椒枯萎病菌具有较好的抑制活性。当浓度为125μg/mL时,硫醚类化合物3d对水稻稻瘟病菌、小麦赤霉病菌、辣椒枯萎病菌的抑制率分别为58.40%,52.12%,61.83%。

The target compounds of thioether ethers were synthesized from 1-carvone via chlorination and nucleophilic substitution. The structures of the title compounds were characterized by elemental analyses, IR, ^1H NMR and 13 C NMR spectra. The results of bioassay showed that compound 3 d had good antifungal activity against Pyricularia oryzae （Hebert） Barr, Fusarium graminearm （Schw） and Fusarium oxysporum Schl. f. sp vasinfectum （ Atk. ） Snyd. ＆Hans, with inhibition rate of 58.40% , 52.12% and 61.83% , respectively, at the concentration of 125 μg/mL.