摘要
采用1#2、#、4#全染色体涂染探针联用的荧光原位杂交(FISH)技术,检测60Coγ射线诱发正常人染色体稳定性畸变的易位率,建立剂量-效应关系,拟合的最佳回归方程为Y=0.0132+0.0757D+0.0158D2。实际应用验证结果表明,在远期受照生物剂量估算中,该剂量-效应关系有良好的应用价值和应用前景。
Chromosome translocation from healthy human peripheral blood induced by 60Co ray in dose response curve was detected using fluorescence in situ hybridization 1#,2# and 4# probes,in order to estimate biological dose of 2 victims exposed to nuclear accident in Xinzhou.The dose response curve was Y=0.013＋0.08D ＋0.016D2,which was used for reconstruction of previous radiation dose.The result indicated that dose estimation for long term radiation exposure could be carried out with FISH established in this study.
出处
《辐射防护通讯》
2010年第3期25-29,共5页
Radiation Protection Bulletin
基金
山西省青年科技研究基金资助项目(20051049)
