缺氧诱导因子1-α及血管内皮生长因子与2型糖尿病微血管并发症的关系

Relationship of Serum Vascular Endothelial Growth Factor and Hypoxia-inducible Factor-1α with Microvascular Complications in Type 2 Diabetic Patients

目的探讨2型糖尿病(T2DM)微血管并发症患者血清血管内皮生长因子(VEGF)和缺氧诱导因子-1α(HIF-1α)水平的变化及其意义。方法对T2DM组108例和健康体检者30人进行研究,根据尿白蛋白排泄率将糖尿病患者分为正常白蛋白尿组(40例)、微量白蛋白尿组(36例)和临床白蛋白尿组(32例)。测定各组血清VEGF、HIF-1α、胆固醇、三酰甘油、肌酐、空腹血糖和胰岛素等,并进行比较。结果 T2DM患者正常白蛋白尿组、微量白蛋白尿组、临床白蛋白尿组的VEGF水平分别为(382.66±50.83)、(452.37±61.35)、(582.29±52.76)ng/L,HIF-1α分别为(78.33±21.02)、(98.46±32.55)、(120.17±31.46)pg/L,均显著高于对照组的(301.18±51.26)ng/L和(52.17±17.38)pg/L(P<0.01);VEGF和HIF-1α水平均随尿白蛋白排泄率的增加而增加。结论 T2DM患者体内高水平的血清VEGF和HIF-1α可能在微血管并发症的发生发展过程中有重要作用。

Objective To explore the changes and significance of vascular endothelial growth factor（VEGF） and hypoxia-inducible factor-1α（HIF-1α） in serum level in type 2 diabetics（T2DM） with microangiopathy.Methods A total of 108 T2DM was divided into 3 groups according to urinary albumin excretion rate（UAER） ：the normal urine protein group（n = 40）,micro albuminuria group（n = 36） and clinical proteinuria group（n = 32）.The other 30 healthy cases were taken as the controls.VEGF,HIF-1α,total cholesterol（TC）,triglyceride（TG）,creatinine,fasting glucose and insulin were measured and compared in all the groups.Results The level of VEGF of the T2DM in the normal urine protein group,micro albuminuria group and clinical proteinuria group were（382.66 ± 50.83）,（452.37 ± 61.35）,（582.29 ± 52.76） ng/L,HIF-1α were（78.33 ± 21.02）,（98.46 ± 32.55）,（120.17 ± 31.46） pg/L.These data were significantly higher than those in the normal controls [（301.18 ± 51.26） ng/L and（52.17 ± 17.38） pg/L,P 0.01].The levels of VEGF and HIF-1α were increased with the increment of UAER.Conclusion High serum levels of VEGF and HIF-1α may play an important role in the occurrence and development of microangiopathy in T2DM.