半胱氨酸蛋白酶抑制剂C评估肾小球滤过率的临床应用

Clinical Application of Cystatin C in the Evaluation of Glomerular Filtration Rate

【目的】探讨半胱氨酸蛋白酶抑制剂C（CysC）测定结果通过Hoek’s公式推算的肾小球滤过率（GFR）值与^125I同位素标记造影法测定GFR值的相关性。【方法】选取123例临床肾病科病人，通过同位素法测定GFR值与CysC和肌酐（Cr）测定结果推算GFR值进行比对。【结果】测定病人CysC结果通过Hoek＇s公式计算的GFR值与同位素法测定GFR值，呈现良好的相关性（Y=0．9341X＋5．3931，R^2=0．9865），同时病人CysC结果与同位素法测定GFR值也密切负相关（Y=-2E-06X3＋0．0007X2—0．08X＋4．0308，R^2=0．993）。【结论】通过CysC测定值用Hoek＇s公式计算GFR值，可以简化GFR测定程序，又可以获得准确的GFR值，帮助临床诊断。

[Objective]To compare Hoek＇s formula with cystatin C（CysC） and ^125I-labeled contrast radiography for estimating glomerular filtration rate（GFR）. [Methods]Totally 123 patients in the department of nephrology were selected. Isotope method for estimating GFR was compared with CysC for estimating GFR. [Results] GFR value calculated by Hoek＇s formula with CysC concentration had good correlation with GFR value obtained by isotope method（Y--0. 9341X＋ 5. 3931,Rz 0. 9865）. The GFR obtained from CysC con- centration had closely inverse correlation with GFR obtained by isotope method（Y= -2E-06X3 ＋ 0. 0007X2 - 0.08X ＋ 4. 0308,R^2=0. 993）. [Conclusion] GFR calculated by Hoek＇s formula with CysC concentration can simplify the procedure of GFR measurement and obtain accurate GFR value which is helpful for the clinical diagnosis.