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老年人腹部手术中采用不同参数行IPPV的肺保护作用研究

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摘要 【目的】研究65~75岁择期行腹部手术的老年患者在仰卧位、全麻、吸入纯氧状态下以不同潮气量行间竭正压机械通气(IPPV)对术中术后各阶段血气及氧自由基指标的影响。【方法】40例随机分为:常规潮气量组(TV,潮气量10mL/kg,20例);小潮气量组(LV,潮气量6mL/kg,20例)。分别于麻醉前、插管后切皮前、手术60min、缝皮后、拔管后30min和手术结束后8h记录生命体征、血气分析、SOD及MDA值。【结果】术中两组间比较PaCO2、PaO2无显著性差异(P〉0.05),术后两组间血气分析指标无明显差异(P〉0.05),拔管后30minPaCO2均值高于麻醉前(P〈0.05);Rf、PaO2较麻醉前明显下降(P〈0.05),两组SOD的消耗币MDA的增长也于拔管后30min达到高峰期,且两组间差异显著(P〈0.05)。【结论】小潮气量控制通气可能有助于术后减轻炎性反应对肺组织的损害。
作者 肖卫东
出处 《医学临床研究》 CAS 2010年第8期1498-1501,共4页 Journal of Clinical Research
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