3753例妇女宫颈人乳头状瘤病毒感染状况分析

Analysis on infection status of cervical human papillomavirus in 3753 women

目的:探讨3753例妇科门诊就诊人群宫颈人乳头状瘤病毒(human papillomavirus,HPV)感染率以及基因亚型的分布特征。方法:采用核酸分子快速导流杂交基因芯片技术(flow-through hybridization and geno-typing technique,Hybri-Max)对3753例妇科门诊就诊患者的宫颈刷片标本进行HPV分型检测,并对HPV感染亚型进行分析。结果:3753例妇女中检测出HPV阳性591例,阳性率为15.7%,其中两种亚型混合感染114例,占总感染人数19.3%(114/591),3种及3种以上亚型混合感染18例,占4.7%(18/591)。人群中感染最多的亚型依次是HPV52(3.9%)、HPV16(3.8%)、HPV58(2.1%)和HPV18(1.2%)。各年龄段妇女HPV感染率差异无统计学意义(χ2=12.42,P>0.05)。结论:妇科门诊就诊人群的HPV感染率为15.7%,且以高危型HPV感染为主,其中最常见的感染亚型是HPV52。

Objective：To explore the infection rate of cervical human papillomavirus （HPV） and the distribution characteristics of HPV gene subtypes in 3 753 women at gynecologic outpatient department.Methods：HPV gene subtypes detection of cervical samples was conducted in 3 753 women at gynecologic outpatient department by nucleic acid molecule flow-through hybridization and geno-typing technique.Results：591 HPV positive women （15.7%） were detected among the 3 753 women,114 women had mixed infection of two subtypes,accounting for 19.3%,18 women had mixed infection of three or more than three subtypes,accounting for 4.7%;the infection rates of subtypes from high to low were HPV52 （3.9%）,HPV16 （3.8%）,HPV58 （2.1%） and HPV18 （1.2%）;there was no significant difference in HPV infection rate among different age groups （χ2=12.42,P0.05）.Conclusion：The infection rate of HPV in women at gynecologic outpatient department is 15.7%,high risk HPV subtypes are the major subtypes,the most common subtype is HPV52.