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转化生长因子β1及其受体在沙眼衣原体感染大鼠子宫组织中的过表达

Over-expression of TGF-β1 and its receptor in cervical tissues of rats with chlamydia trachomatis infection
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摘要 目的:探讨沙眼衣原体(CT)感染生殖道对妊娠的影响和CT感染的致病机制以及细胞因子TGF-β1及其受体TGF-β-R1与妊娠之间的关系。方法:建立CT感染大鼠模型,取大鼠妊娠子宫组织进行逆转录PCR,并利用免疫组织化学方法检测转化生长因子β1及其受体蛋白的分布情况和表达变化。结果:TGF-β1及其受体主要表达在腺体及蜕膜细胞中;感染组中TGF-β1及其受体的表达量明显高于对照组。结论:TGF-β1及其受体在CT感染的孕鼠蜕膜组织中的过表达与病理妊娠具有直接相关性。 Objective：To explore the effect of reproductive tract infection of chlamydia trachomatis （CT） on pregnancy,the mechanism of CT infection and the relationship between transforming growth factor-β1 （TGF-β1）,transforming growth factor receptor 1 （TGF-β-R1） and pregnancy.Methods：The rat models of CT infection were established,then the cervical samples of pregnant rats were taken for RT-PCR,and the distribution situations and expression changes of TGF-β1 and TGF-β-R1 were detected by immunohistochemistry.Results：TGF-β1 and its receptor mainly expressed in glandular cells and decidual cells;the expression levels of TGF-β1 and its receptor in infection group were significantly higher than those in control group.Conclusion：The over-expressions of TGF-β1 and its receptor in decidual tissues of CT infected pregnant rats are related to pathological pregnancy.
作者 王倩倩 王燕舞 李晓兰 黎莉 孟运莲
机构地区 武汉大学基础医学院组织胚胎学教研室
出处 《中国妇幼保健》 CAS 北大核心 2010年第24期3484-3487,共4页 Maternal and Child Health Care of China
关键词 沙眼衣原体 胚胎植入 TGF-β1 TGF-β-R1 Chlamydia trachomatis Embryo implantation Transforming growth factor-β1 Transforming growth factor receptor 1
分类号 R518.5 [医药卫生—内科学]
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参考文献10

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二级参考文献12

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中国妇幼保健
2010年 第24期

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