抗心磷脂抗体与复发性脑梗塞关系的初步探讨

The detection of the relationship between anticardiolipin antibodies and recurrent cerebral infarction

目的：探讨抗心磷脂抗体（ＡＣＬＡ）与复发性脑梗塞（ＲＣＩ）的关系。方法：采用ＥＬＩＳＡ方法检测了３７例ＲＣＩ患者和６８例首发性脑梗塞（ＦＣＩ）患者的血清ＡＣＬＡ，并与对照组５０例进行比较。结果：ＲＣＩ、ＦＣＩ及对照组的ＡＣＬＡ阳性率分别为６４．８６％、３２．３５％及１６％，ＲＣＩ及ＦＣＩ组的ＡＣＬＡ阳性率与对照组ＡＣＬＡ阳性率比较差异均有统计学意义（Ｐ＜０．０１、Ｐ＜０．０５）；同时ＲＣＩ组ＡＣＬＡ阳性率也明显高于ＦＣＩ组ＡＣＬＡ阳性率（Ｐ＜０．０１）。阳性病例ＡＣＬＡ分型中，ＲＣＩ及ＦＣＩ组中ＩｇＧ型ＡＣＬＡ阳性率与对照组ＩｇＧ型ＡＣＬＡ阳性率比较差异有统计学意义（Ｐ＜０．０１），ＲＣＩ组中ＩｇＭ型ＡＣＬＡ阳性率也明显高于对照组ＩｇＭ型ＡＣＬＡ阳性率（Ｐ＜０．０５）。ＲＣＩ组中男女人数比值为３．６３。结论：ＡＣＬＡ可能为ＲＣＩ发生的危险因素。

Objective:To identify the relationship betwween anticardiolipin antibodies and recurrent cerebral infarction(RCI).Methods:The positive rates of ACLA in plasma in 37 patients with RCI,68 patients with first cerebral infarction(FCI),and 50 control subjects were evaluated,using ELISA methods.Results:The results showed that the positive rates of ACLA in patients with RCI,FCI,and in control subjects were 64.86%,32.35%,and 16% respectively.The statistical significant differences among the RCI group,the FCI group and the control group were found for the positive rate of ACLA(P<0.01,P<0.05).In the meantime,we found that the positive rates of IgG type ACLA were significantly higher in patients with RCI and FCI than in control subjects(P<0.01),the positive rate of IgM type ACLA was much higher in patients with RCI than in control subjects(P<0.05).Conclusion:The results suggested that ACLA might be an important risk factor for RCI.