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诺和锐30强化治疗对老年2型糖尿病患者胰岛细胞功能影响 被引量:1

Effects of intensive insulin therapy by BIAsp 30 on elderly patients with type 2 diabetes islet cell function
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摘要 目的探讨短期诺和锐30强化治疗对老年患者胰岛细胞功能的影响。方法对30例初诊老年2型糖尿病患者进行每日3次诺和锐30强化治疗2周,治疗前后分别行静脉葡萄糖耐量实验,测定0,3,4,5,8,10,120分钟血糖、胰岛素、C肽,计算胰岛素及C肽曲线下面积(AUC)、稳态模型胰岛素抵抗指数(HOMA-IR)、胰岛β细胞分泌功能的HOMA-β指数。结果患者治疗后血清胰岛素及C肽第一时相分泌明显增加,HOMA-β指数明显升高,HOMA-IR指数下降。结论短期每日3次诺和锐30强化治疗能明显改善老年2型糖尿病患者胰岛细胞的分泌功能。 Objective To explore the effects of transient intensive therapy with BIAsp30 on elderly patients with type 2 diabetes islet cell function.Methods Thirty first diagnosed old age type 2 diabetics were treated with thrice daily BIAsp30 for 2 weeks.Intravenous glucose tolerance tests(IVGTT) were performed before and after the treatments.During IVGTT,levels of blood glucose,insulin and C-peptide at 0,3,4,5,8,10,120 minutes were measured.AUC of insulin and C-peptide were calculated.Results After treatment,AUC0-10min of insulin was increased from 64.93±21.08 mU×min/L to 105.89±64.80 mU×min/L (P0.01) and C-peptide from 6.63±0.53 nmol×min/L to 9.46±0.63 nmol×min/L(P0.01).Furthermore,HOMA-IR index was decreased and HOMA-β index was increased (P0.01).Conclusion Thrice daily BIAsp30 intensive insulin therapy significantly improves the secretion function of islet cell in elderly patients with type 2 diabetic.
出处 《中国老年保健医学》 2010年第4期56-57,共2页 Chinese Journal of Geriatric Care
关键词 胰岛素强化治疗 诺和锐30 2型糖尿病 第一时相胰岛素分泌 胰岛β细胞 Intensive insulin therapy BIAsp30 Diabetes type 2 First-phase insulin secretion Islet cell
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参考文献5

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二级参考文献19

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