诺和锐30强化治疗对老年2型糖尿病患者胰岛细胞功能影响

Effects of intensive insulin therapy by BIAsp 30 on elderly patients with type 2 diabetes islet cell function

目的探讨短期诺和锐30强化治疗对老年患者胰岛细胞功能的影响。方法对30例初诊老年2型糖尿病患者进行每日3次诺和锐30强化治疗2周,治疗前后分别行静脉葡萄糖耐量实验,测定0,3,4,5,8,10,120分钟血糖、胰岛素、C肽,计算胰岛素及C肽曲线下面积(AUC)、稳态模型胰岛素抵抗指数(HOMA-IR)、胰岛β细胞分泌功能的HOMA-β指数。结果患者治疗后血清胰岛素及C肽第一时相分泌明显增加,HOMA-β指数明显升高,HOMA-IR指数下降。结论短期每日3次诺和锐30强化治疗能明显改善老年2型糖尿病患者胰岛细胞的分泌功能。

Objective To explore the effects of transient intensive therapy with BIAsp30 on elderly patients with type 2 diabetes islet cell function.Methods Thirty first diagnosed old age type 2 diabetics were treated with thrice daily BIAsp30 for 2 weeks.Intravenous glucose tolerance tests（IVGTT） were performed before and after the treatments.During IVGTT,levels of blood glucose,insulin and C-peptide at 0,3,4,5,8,10,120 minutes were measured.AUC of insulin and C-peptide were calculated.Results After treatment,AUC0-10min of insulin was increased from 64.93±21.08 mU×min/L to 105.89±64.80 mU×min/L （P0.01） and C-peptide from 6.63±0.53 nmol×min/L to 9.46±0.63 nmol×min/L（P0.01）.Furthermore,HOMA-IR index was decreased and HOMA-β index was increased （P0.01）.Conclusion Thrice daily BIAsp30 intensive insulin therapy significantly improves the secretion function of islet cell in elderly patients with type 2 diabetic.