玻璃酸钠注射配合体外冲击波治疗膝骨关节炎的临床观察

Combination of Intra-articular Injection of Hyaluronate and Extracorporeal Shock Wave Therapy on Knee Osteoarthritis

目的观察膝关节腔注射玻璃酸钠配合体外冲击波治疗膝骨关节炎的疗效。方法 50例膝骨关节炎患者分为两组:研究组(关节腔注射玻璃酸钠配合体外冲击波治疗,n=22)和对照组(关节腔注射玻璃酸钠配合复方倍他米松痛点注射,n=28),关节腔注射治疗均为每周1次,5周为1个疗程。于治疗前及结束后1周记录安静时疼痛、运动时疼痛、疼痛消失的时间、应用糖皮质激素或体外冲击波治疗的次数、患者治疗后的疗效及副作用。结果治疗后两组患者症状均明显缓解,除治疗1周时对照组症状减轻程度较研究组明显(P<0.01)外,其余各时间段两组疗效均相当(P>0.05)。结论关节腔注射玻璃酸钠结合体外冲击波治疗膝骨关节炎安全有效。

Objective To investigate the therapeutic efficacy and side effect of combination of intra-articular injection of hyaluronate and extracorporeal shock wave therapy（ESWT） on patients with knee osteoarthritis.Methods 50 patients with knee osteoarthritis were treated by combination of intra-articular injection of hyaluronate and ESWT（study group,n=22） or combination of intra-articular injection of hyaluronate and pain-point injection of betamethasone（control group,n=28）. The parameters included pain intensity （Numeric Rating Score,NRS） at rest and at exercise,pain relief rate,the time when pain disappeared and times of betamethasone administration or ESWT. The side effects were also evaluated.Results NRS decreased in the two groups after treatment,while NRS was not different betweenthe two groups（P0.05） except 1 week after the treat ment（P0.01）.Conclusion The combi-nation of intra-articular injection of hyaluronate and extracorporeal shock wave is a safe and effective treat ment for knee osteoarthri-tis.