叶下珠中新多酚化合物的分离与鉴定

ISOLATION AND IDENTIFICATION OF A NOVEL POLYPHENOLIC COMPOUND FROM PHYLLANTHUS URINARIA

目的：研究植物药叶下珠（ＰｈｙｌａｎｔｈｕｓｕｒｉｎａｒｉａＬ．）的化学成分。方法：用各种色谱技术进行分离纯化，经ＭＳ，１Ｈ，１３ＣＮＭＲ和ＨＭＢＣ光谱分析鉴定其结构。结果：分得４个多酚类化合物，其结构分别鉴定为１Ｏ没食子酰基３，６六羟基联苯二甲酰基２，４去羟甲基诃子酰基吡喃葡糖（Ｉ），焦酚（ｐｙｒｏｇａｌｏｌ，Ｉ），咖啡酸（ｃａｆｅｉｃａｃｉｄ，ＩＩ）和（ｂｒｅｖｉｆｏｌｉｎｃａｒｂｏｘｙｌｉｃａｃｉｄ，ＩＶ）。结论：化合物Ｉ为一新的鞣花单宁（命名为ｐｈｙｌａｎｔｈｕｓｉｎＵ），Ｉ，ＩＩ，ＩＶ为首次从该植物中分得。

AIM: To study the chemical constituents the medicinal plant Phyllanthus urinaria L. METHODS: The constituents were separated and purified by using various chromatographies. The structural elucidation of the compounds were based on the analysis of their MS, 1H & 13 CNMR and HMBC spectra. RESULTS: Four polyphenolic compounds were obtained from P.urinaria and their structures were identified as: 1 O galloyl 3,6 O HHDP 2,4 O dehydroxymethyl chebuloyl β D glucopyranose (I), pyrogallol (II), caffeic acid (III) and brevifolincarboxylic acid (IV). CONCLUSION: Compound I was found to be a novel ellagitannin, named phyllanthusiin U, and II～IV were isolated from this plant for the first time.