EphA2和E-cadherin在膀胱尿路上皮癌中的表达及意义

Expression and significance of EphA2 and E-cadherin in bladder urothelium carcinoma

目的:探讨生促红素人肝细胞A2(erythropoietin-producing human hepatocelluar A2,EphA2)和E-钙黏蛋白(E-cadherin)在膀胱尿路上皮癌(bladder urothelium carcinoma,BTCC)中的表达及临床意义。方法:应用免疫组织化学方法检测10例正常膀胱黏膜和50例BTCC标本EphA2和E-cadherin表达情况。结果:10例正常膀胱黏膜标本中EphA2表达均为阴性,而E-cadherin表达为正常表达;50例BTCC标本中EphA2和E-cadherin异常表达率分别为80.0%、56.0%。EphA2表达与分级和分期间差异均有统计学意义(P<0.05),与淋巴结转移无明显关系(P>0.05);E-cadherin表达与分级、分期间差异均有统计学意义(P<0.05),与淋巴结转移有一定关系(P=0.008)。二者在BTCC中的表达呈负相关关系(P<0.05)。结论:EphA2和E-cadherin表达与BTCC生物学行为密切相关,联合检测EphA2和E-cadherin可作为判断BTCC恶性程度的指标。

Objective：To investigate the expressions and clinical significance of erythropoietin-producing human hepatocelluar A2（EphA2）and E-cadherin in bladder urothelium carcinoma（BTCC）.Methods：The expressions of EphA2 and E-cadherin proteins were detected by immunohistochemisty in 50 cases of BTCC and 10 cases of normal bladder mucosa.Results：The expression of EphA2 was negative and the E-cadherin expression was normal in all the 10 normal bladder mucosa.Abnormal EphA2 and E-cadherins expressions were found in 40 and 28 cases of BTCC（80.0%,56.0%）.Abnormal EphA2 expression was positively related to the grade and the stage of BTCC（P0.05）,but negatively related to lymph node metastasis（P0.05）.Abnormal E-cadherin expression was negatively correlated to the grade,stage（P0.05）and lymph node metastasis（P=0.008）.The expression of EphA2 was inversely correlated with that of E-cadherin in BTCC（P0.05）.Conclusions：The expressions of EphA2 and E-cadherin are closely related to the biological behavior of BTCC.Detection of EphA2 and E-cadherin in BTCC may have prognostic value for the degree of malignancy.