慢性阻塞性肺疾病患者血清环氧化酶-2和地诺前列酮浓度变化的临床意义

Clinical significance of changes of serum cyclooxygenase-2 and dinoprostone concentrations in patients with chronic obstructive pulmonary disease

目的:探讨慢性阻塞性肺疾病(COPD)患者急性发作期和缓解期血清环氧化酶-2(COX-2)和地诺前列酮浓度变化的临床意义。方法:采用ELISA法,分别检测48例COPD患者在急性发作期、缓解期及53名健康人(对照组)血清COX-2和地诺前列酮浓度,并进行比较。同时测定COPD急性发作期血清C反应蛋白(CRP)浓度。结果:COPD急性发作期、缓解期COX-2、地诺前列酮均明显高于对照组(P<0.01);急性发作期和缓解期比较血清地诺前列酮浓度差异亦有统计学意义(P<0.01),而COX-2浓度则无明显不同(P>0.05);急性发作期COX-2和地诺前列酮浓度与CRP浓度之间均呈正相关关系(P<0.01和P<0.05),COX-2浓度和地诺前列酮浓度之间亦呈正相关关系(P<0.01)。结论:COX-2和地诺前列酮参与了COPD的炎症过程,检测地诺前列酮血清浓度有助于对COPD急性发作进行监测。

Objective：To investigate the clinical significance of serum cyclooxygenase-2（COX-2） and dinoprostone concentrations variation in patients with chronic obstructive pulmonary disease（COPD） during the acute exacerbation and the stable period.Methods：Enzyme-linked immunosorbent assay was used to measure the serum concentrations of COX-2 and dinoprostone in 53 health controls and 48 patients with COPD during the acute exacerbation and the stable period.Meanwhile the serum concentration of C-reactive protein was measured in patients with COPD during the acute exacerbation.Results：The serum concentrations of COX-2 and dinoprostone in patients with COPD during the acute exacerbation and the stable period were both significantly higher than those of the control（P0.01）.The serum concentration of dinoprostone during the acute exacerbation was significantly higher than that in the stable period（P0.01）,while COX-2 did not differ significantly in the two groups;during the acute exacerbation,the serum concentrations of COX-2 and dinoprostone showed positive correlation with the concentration of C-reactive protein（P0.01 and P0.05）,and there was also a positive correlation between COX-2 and dinoprostone concentrations（P0.01）.Conclusions：COX-2 and dinoprostone are both involved in the inflammation activity.The serum concentration of dinoprostone may help to determine the condition of COPD during the acute exacerbation.