阿魏酸钠对肾脏缺血再灌注损伤大鼠肾脏组织病理学影响的实验研究

The experiment research about the effect of sodium ferulate to the organization pathology of rat kidney which was experienced ischemia reperfusion injury

目的研究阿魏酸钠对肾脏缺血再灌注损伤(RIRI)大鼠肾脏组织病理学的影响。方法建立大鼠肾脏缺血再灌注损伤模型,取出正常对照组、假手术组、肾脏缺血再灌注损伤模型对照组(模型对照组)、肾脏缺血再灌注损伤阿魏酸钠治疗组(模型治疗组)的大鼠肾组织,分别做常规HE、PAS染色。结果经阿魏酸钠治疗的模型治疗组大鼠的肾组织病理有明显改善。结论阿魏酸钠对大鼠肾脏缺血再灌注损伤有保护作用。

Objective To investigate the effect of sodium ferulate to the organization pathology of rat kidney which was experienced ischemia reperfusion injury. Methods 40 rats were distributed to four groups at random. The first is normal control group. The second is sham operation group, The third is renal ischemia-reperfusion model group and the forth is renal ischemia-reperfusion model rat used sodium ferulate group. Then the renal samples were dyed HE and PAS. Results The organization pathology of renal ischemi- a-reperfusion model rat used sodium ferulate made better distinctly. Conclusion The sodium ferulate had the protective action to the renal ischemia-reperfusion model rat.