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胰高血糖素样肽-2研究的新进展 被引量：5

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摘要 胰高血糖素样肽-2（glucagon-like peptide-2,GLP-2）是胰高血糖素原基因转录、翻译后处理加工的33氨基酸的多肽,GLP-2经二酰肽酶Ⅳ水解后,则失去生物学活性。GLP-2作为一种肠上皮特异性生长因子,能促进正常肠黏膜的生长及损伤肠上皮的修复。GLP-2通过作用于GLP-2受体（GLP-2R）来发挥生物学作用。GLP-2R在肠道的广泛分布（肠上皮细胞、肠内在神经元、肠内分泌细胞、肠黏膜下的肌纤维母细胞）,提示GLP-2可能通过直接、间接等多条途径发挥生物学作用。本文概括介绍GLP-2的特性、生理作用及机制等方面的研究进展。
作者 吴云红 朱亮 邹原 宫德正
机构地区 大连医科大学药事管理教研室 大连医科大学生理学教研室
出处 《生理科学进展》 CAS CSCD 北大核心 2010年第4期283-286,共4页 Progress in Physiological Sciences
基金 国家自然科学基金资助课题(30801127)
关键词 胰高血糖素样肽-2 生物学作用 胰高血糖素样肽-2受体
分类号 R333 [医药卫生—人体生理学]
  • 相关文献

参考文献10

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二级参考文献26

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共引文献9

同被引文献53

  • 1蒋义,贾刚,惠明弟,陈小玲,李华,王康宁.胰高血糖素样肽-2对断奶仔猪肠上皮紧密连接蛋白相关基因表达的影响[J].动物营养学报,2012,24(9):1785-1792. 被引量：14
  • 2余长松,贾刚,邓秋红,陈小玲,赵华,刘光芒,王康宁.胰高血糖素样肽-2对脂多糖应激的IPEC-J2细胞形态和紧密连接相关基因表达的影响[J].畜牧兽医学报,2015,46(4):592-599. 被引量：9
  • 3王丽娜,陈杰,赵茹茜.胰高血糖素样肽-2及其受体与胃肠道的发育[J].畜牧与兽医,2006,38(1):55-57. 被引量：4
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  • 6Cani PD, Neyrinck AM, Fava F, et al. Selective increases of bifi- dobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia [J]. Diabetologia, 2007, 50 (11): 2374-2383.
  • 7Backhed F, Ding Hao, Wang Ting, et al. The gut microbiota as an environmental factor that regulates fat storage [J]. Proc Natl A- cad Sci U S A, 2004, 101 (44): 15718-15723.
  • 8Cani PD, Possemiers S, Van de Wiele T, et al. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability [J]. Gut, 2009, 58 (8): 1091-1103.
  • 9US FDA. FDA approves Gattex to treat short bowel syndrome [ EB/OL ]. [ 2012-12-21 ]. http://www, fda. gov/NewsEv- ents/Newsroom/PressAnnouncements/ucm333171, htm.
  • 10王亚里,孙长安,王瑞军,等.胰高血糖素样肽-2类似物及其制备方法和用途:中国,101824087[P].2010-09-08.

引证文献5

二级引证文献11

生理科学进展
2010年 第4期

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