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SRC-3与乳腺癌的关系研究进展 被引量:3

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摘要 类固醇受体辅助活化因子-3(SRC-3)是p160类固醇受体辅助活化因子SRC基因家族的成员,与体内多种肿瘤的形成密切相关。SRC-3不仅可以通过多种信号转导通路参与乳腺癌的发生,还与部分乳腺癌患者产生内分泌药物治疗抵抗的分子机制有关。临床治疗研究中发现,SRC-3和人表皮生长因子受体-2的共同过度表达常预示着乳腺癌患者较差的生存率。因此,SRC-3有望成为抗癌治疗的新靶点,解决目前内分泌治疗的药物抵抗问题,给更多乳腺癌患者带来福音。
出处 《生理科学进展》 CAS CSCD 北大核心 2010年第4期299-303,共5页 Progress in Physiological Sciences
基金 第三军医大学回国人员启动基金(TMMU,2007XG41) 重庆市回国人员启动基金(CSTC,2007BB5030)资助课题
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