正交实验法制备甲硝唑-β-环糊精包合物

Preparation of metronidazole-β-cyclodextrin inclusion compound by orthogonal design

目的研究甲硝唑-β-环糊精包合物的制备工艺,提高甲硝唑的溶解度。方法用饱和溶液法制备包合物,并用正交设计法优化甲硝唑-β-环糊精包合物的最佳制备条件。结果以包合物的收率和包合率为指标筛选出甲硝唑-β-环糊精最佳包合条件为:甲硝唑β-环糊精为12,包合时间4h,包合温度50℃。结论甲硝唑与β-环糊精可形成稳定的包合物,该制剂制备简单,包合工艺稳定可行,可进一步制成较理想的其他剂型。

Objective To study the preparation technology of the inclusion compound of metronidazole-β-cyclodextrin and to improve its solubility. Methods Inclusion compound was prepared with the saturated solution method,and an orthogonal test was used to optimize the conditions for the technology of preparation. Results By inspecting availability and inclusive ratio, the optimal conditions for the inclusion compound of the drug were： metronidazole：β-cyclodextrin = 1：2,time for inclusion： 4 h,inclusion temperature： 50 ℃ . Conclusion The metronidazole and β-cyclodextrin can get stable inclusion compound. The preparation is simple and the technology is feasible. The inclusion compound can be further made other ideal dosage form.