抗幽门螺杆菌治疗慢性胃炎伴缺铁性贫血69例

Anti-Helicobacter pylori in treating chronic gastritis with iron deficiency anemia for 69 cases

目的观察抗幽门螺杆菌(Hp)治疗慢性胃炎伴缺铁性贫血(IDA)的疗效。方法 136例慢性胃炎伴IDA患者分为观察组和对照组,观察组69例采用抗Hp+铁剂治疗,对照组67例单用铁剂治疗,2组均治疗12周。于治疗开始后每2周复查血红蛋白(Hb),第8、12周复查血清铁(SI)、血清铁蛋白(SF),并比较2组疗效。结果治疗8、12周后,观察组和对照组Hb、SI和SF均较治疗前升高,差别有统计学意义(P<0.05);治疗8、12周后,观察组Hb、SI和SF均高于对照组,差别有统计学意义(P<0.05)。观察组有效率(82.6%)高于对照组(53.7%)(P<0.05)。结论根除Hp治疗可加快Hb上升,增加铁贮存量,是治愈IDA患者的有效方法。

Objective To observe the efficacy of anti-Helicobacter pylori in treating chronic gastritis with iron deficiency anemia. Methods One hundred and thirty-six patients with chronic gastritis with iron deficiency anemia were divided into observation group and control group. Sixty-nine cases in observation group were treated with anti-Helicobacter pylori plus chalybeate, while sixty-seven cases in control group were treated with chalybeate only. The two groups all were treated for two weeks. Hemoglobin was rechecked every two weeks after treatment,serum iron and serum ferritin were rechecked in the eighth week and twelfth week after treatment. Then the curative effect was compared between two groups. Results After 8 and 12 weeks for treatment,hemoglobin,serum iron and serum ferritin increased significantly in the two groups compared with before treatment（ P 〈0. 05） ,and the three indexes in observation group were higher than those in control group（ P 〈0. 05） . The total effective rate of the observation group was 82. 6% which was higher than that in the control group（ 53. 7% ） （ P〈 0. 05） . Conclusion Eradication of Helicobacter pylori infection can increase inventory of iron and it can cure chronic gastritis with iron deficiency anemia efficiently.