大黄对重症急性胰腺炎患者血清C反应蛋白和细胞间黏附分子-1的影响

Effects of Rhubarb on Serum C-reactive Protein and Intercellular Adhesion Molecule-1 in Patients with Severe Acute Pancreatitis

目的观察大黄治疗重症急性胰腺炎的临床疗效及其对重症急性胰腺炎患者血清C反应蛋白(C-reactiveprotein,CRP)和细胞间黏附分子1(intercellular adhesion molecule 1,ICAM-1)的影响。方法将50例重症急性胰腺炎患者按随机数字表法分为2组:试验组和对照组,每组25例。对照组采用常规治疗。在此基础上,试验组加用大黄粉治疗。观察2组患者治疗后腹痛缓解时间和体温、肠鸣音、血淀粉酶恢复时间、临床疗效及治疗后第5、10天血清CRP、ICAM-1表达水平的变化等情况。结果试验组痊愈率、总有效率均明显高于对照组(均P<0.05)。试验组腹痛缓解时间及体温、肠鸣音、血淀粉酶恢复时间与对照组比较差异均有统计学意义(均P<0.05)。试验组治疗后第5、10天血清CRP、ICAM-1表达水平与对照组比较差异均有统计学意义(均P<0.05)。结论大黄治疗重症急性胰腺炎有较好的效果,且与下调ICAM-1的表达有关。

Objective To explore the clinical curative effect of rhubarb on severe acute pancreatitis（SAP） and to investigate the mechanism of rhubarb action.Methods Fifty cases of SAP were randomly divided into 2 groups to number table method：control group（conventional therapy group） and rhubarb treatment group（conventional therapy plus rhubarb treatment group）,with 25 cases in each group.The duration of abdominal pain,body temperature,borborygmus,recovery time of blood amylase,clinical curative effect were observed,and the expression of serum C-reactive protein（CRP） and intercellular adhesion molecule-1（ICAM-1） were detected 5 and 10 days after treatment.Results Compared with the control group,the cure rate and the total effective rate increased significantly,and the duration of abdominal pain,body temperature,borborygmus and recovery time of blood amylase were obviously improved in rhubarb treatment group（all P〈0.05）,and the expression of CRP and ICAM-1 decreased remarkably on the 5th and 10th day after rhubarb treatment（all P〈0.05）.Conclusion Rhubarb can improve the effect of conventional therapy on SAP,which may be associated with the downregulation of ICAM-1 expression.