术前放化疗对中晚期直肠癌保肛手术的临床作用价值

Clinical Value of Preoperative Radiotherapy and Chemotherapy for Advanced Rectal Cancer Surgery Anus

目的探讨术前放化疗对中晚期进展期直肠癌保肛手术的临床价值。方法选取郑州人民医院72例直肠癌患者,随机将患者平均分成两组,观察组患者给予术前新辅助放、化疗,对照组患者同期直接手术。随访分析两组患者保肛率及3a生存率。结果近期疗效上,观察组总有效率明显优于对照组(P<0.05);远期疗效上,两组3a生存率及术中淋巴结阳性率之间差别均有统计学意义(P<0.05);两组保肛率差异也有统计学意义(P<0.05)。结论术前加用放化疗在提高直肠癌患者保肛率的同时,可以提高患者3a生存率和降低淋巴结转移率,减少手术并发症和局部复发率。但其最终结果和远期疗效有待进一步观察和分析。

Objective Analyze the clinical value of Preoperative radiotherapy and chemotherapy for advanced rectal cancer surgery anus. Methods We select 72 cases of rectal cancer in our hospital, patients were randomly divided into two groups on average, the observation group were treated with preoperative neoadjuvant chemotherapy and radiotherapy in the control group over the same period in patients with direct surgery, Follow-up of two/groups of patients with anal sphincter preservation rate and the 3-year survival rate. Results The short-term effect, the total of the observation group is markedly superior to the control group（P〈0.05） ; long-term effect, the two sets of 3-year survival rate and intraoperative lymph node-positive were statistically significant differences between the rate （P〈 0.05） ; two groups Sphincter preservation rates are also statistically significant differences（P〈0.05）. Conclusion Preoperative radiotherapy and chemotherapy was added to enhance the rate of cancer patients, while anus can enhance the 3-year survival rate in patients with lymph node metastasis rate, reduce surgical complications and local recurrence rate. But the final results and long-term effect needs further observation and analysis.