手术联合^(125)I粒子在治疗直肠癌Miles术后局部复发中的应用

Surgery combined with ^(125)I particle implantation for locally recurrent rectal cancer after Miles′ operation

目的如何提高晚期直肠癌患者的生存率一直是临床的难题。文中探讨手术联合125I粒子术中植入治疗直肠癌miles术后局部复发的效果。方法将72例直肠癌miles术后局部复发患者分成3组:手术切除组(A组),24例;手术+放疗组(B组),28例;手术切除联合125I粒子植入组(C组),20例。跟踪随访3组生存期;同时比较各组并发症的发生情况。结果3组患者生存期分别为18、19和25个月。分析表明,C组患者的生存期略高于A组和B组(P<0.05)。A组和C组患者并发症的发生率比B组低,而C组与A组相比其并发症差异无显著性。结论手术联合125I粒子植入术是治疗直肠癌miles术后局部复发的有效方法。

Objective How to increase the survival rate of the patients with advanced rectal cancer remains a difficult problem.This article investigated the effect of surgery combined with ^125I particle implantation in treatment of locally recurrent rectal cancer after Miles′ operation.Methods Seventy-two patients with locally recurrent rectal cancer after Miles′ operation were treated by three different methods： surgical resection（group A,n=24）,operation followed by radiotherapy（group B,n=28）,and surgery combined with 125I particle implantation（group C,n=20）.All were followed up for the survival time and complications.Results Group C showed a longer survival time than groups A and B（[25±3.78] versus [18±3.49] and [19±2.96] months,P〈0.05） and a lower incidence of complications than group B（P〈0.05）,but with no significant difference from group A（P〉0.05）.Conclusion Surgery combined with 125I particle implication is an effective method for the treatment of locally recurrent rectal cancer after Miles′ operation.