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SIRT1的生物学功能及其在胰岛素抵抗中的作用 被引量：11

The Biological Function of SIRT1 and its Relation with Insulin Resistance
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摘要 SIRT1是NAD+依赖的组蛋白去乙酰化酶,通过使底物发生去乙酰化作用参与了DNA修复、细胞凋亡/细胞生存、细胞分化、内分泌信号通路和衰老等生命过程的调节.SIRT1在胰岛素敏感的组织器官中,通过调节胰岛素相关蛋白之间的相互作用与胰岛素信号转导途径,改善胰岛素敏感性和胰岛素抵抗,并且SIRT1在线粒体损伤中的作用与胰岛素抵抗发生有着密切的联系. Silent information regulator 1（SIRT1）is a NAD＋-dependent histone deacetylase.By deacetylat-ing substrate,SIRT1 plays an important role in the regulation of many life processes such as DNA repair,cell apoptosis and survival,cell differentiation,endocrine signaling pathways and life aging.In the tissues and organs sensitive to insulin,SIRT1 improves insulin sensitivity and resistance by regulating in sulinsignal transduction pathways and the interaction between the insulin-related proteins.Moreover,the effect of SIRT1 in the mitochondrial dysfunction is closely related to the occurrence of insulin resistance.
作者 李莉萍 曾卫民 郭明日
机构地区 中南大学生物科学与技术学院生物化学系 天津市海河医院
出处 《生命科学研究》 CAS CSCD 2010年第4期372-376,共5页 Life Science Research
基金 国家自然科学基金资助项目(30070355)
关键词 沉默信息调节因子1(SIRT1) 生物学功能 胰岛素抵抗 线粒体损伤 silent information regulator 1（SIRT1） biological function insulin resistance mitochondrialdysfunction
分类号 Q578 [生物学—生物化学]
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参考文献22

  • 1YAMAMOTO H, SCHOONJANS K, AUWERX J. Sirtuin functions in health and disease[J]. Molecular Endocrinology, 2007, 21(8): 1745-1755.
  • 2MOYNIHAN K A-, GRIMM A A, PLUEGER M M, et al. Increased dosage of mammalian sir2 in pancreatic beta cells / enhances glucose-stimulated insulin secretion in mice[J]. Cell Metabolism, 2005, 2(2) : 105-117.
  • 3BROOKS C L, GU W. How does SIRT1 affect metabolism, senescence and cancer?[J]. Nature Reviews Cancer, 2009, 9 (2): 123-128.
  • 4SALMINEN A, KAARNIRANTA K. SIRT1: Regulation of longevity via autophagy[J]. Cellular Signalling, 2009, 21 (9): 1356-1360.
  • 5LONGO V D, KENNEDY B K. Sirtuins in aging and agerelated disease[J]. Cell, 2006, 126(2): 257-268.
  • 6HAN M K, SONG E K, GUO Y, et al. SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization[J]. Cell Stem Cell, 2008, 2(3): 241-251.
  • 7VAN DER HORST A, TERTOOLEN L G, DE VRIES-SMITS L M M, et al. FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2 (SIRT1)[J]. The Journal of Biological Chemistry, 2004, 279 (28): 28873- 28879.
  • 8KIM M J, AHN K, PARK S H, et al. SIRT1 regulates tyrosine hydroxylase expression and differentiation of neuroblastoma cells via FOXO3a[J]. FEBS Letters, 2009, 583(7): 1183-1188.
  • 9YOSHIZAKI T, MILNE J C, IMAMURA T, et al. SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes[J]. Molecular and Cellular Biology, 2009, 29(5): 1363-1374.
  • 10MILNE J C, LAMBERT P D, SCHENK S, et al. Small moleule activators of sirt1 as therapeutics for the treatment of type 2 diabetes[J]. Nature, 2007, 450(7170): 712-716.

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生命科学研究
2010年 第4期

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