尿微量白蛋白和β_2-微球蛋白联合检测对糖尿病肾病早期诊断的应用价值

Clinical Value on Combined Detection of Urinary Microalbumin and β_2-microglobulin in the Early Diagnosis of Diabetic Nephropathy

目的：探讨联合检测尿微量白蛋白（mAlb）、尿 β2-微球蛋白（ β2-MG）对糖尿病肾病早期诊断的价值。方法：对152例糖尿病患者组和92例健康对照组用散射比浊法测定尿中微量白蛋白和 β2-微球蛋白（ β2-MG）的含量，并对结果进行统计分析。结果：病程〈5年的糖尿病患者的尿mAlb、 β2-MG与健康对照组比较差异无统计学意义；病程5～10年的患者与健康对照组比较，尿mAlb、 β2-MG差异有统计学意义；病程〉10年的患者尿mAlb、 β2-MG明显高于健康对照组。随着年龄的增长，患者的尿mAlb、 β2-MG浓度也逐渐增加。结论：尿mAlb、 β2-MG联合检测对糖尿病肾病的早期诊断有非常重要的临床参考价值，可作为糖尿病肾病的早期诊断指标。

Objective： To study the value on combined detection of urinary microalbumin（mAlb） and β2-microglobulin （ β2-MG） in the early diagnosis of diabetic nephropathy. Methods： 152 patients with diabetes and 92 healthy controls were tested urinary mAlb and β2-MG levels using nephelometry, and the results were statistically analyzed. Results： The levels of urinary mAlb and β2-MG there were no significant difference in the patients whose course of diabetes shorter than 5 years with the healthy group. But it showed significant in the patients whose course of disease 5 to 10 years comparing with the control group. In the group of course ~10 years, urinary mAlb and β2-MG were higher than the controls. So the level of mAlb and β2-MG would in crease following age increasing. Conclusion.. The combined detection of urinary mAlb and β2-MG had important clinical value in the early diagnosis ol diabetic nephropathy.