摘要
合成并表征8-羟基喹啉-2-醛-苯甲酰腙Cu(II)配合物(2 a)和8-羟基喹啉-2-醛-对羟基苯甲酰腙Cu(II)配合物(2b),利用黏度滴定、紫外光谱和荧光光谱法研究它们与CT-DNA相互作用情况.实验结果表明,配合物2 a和2b均为良好的DNA插入试剂,它们与DNA的结合常数分别为1.162×106L.mol-1和6.934×106L.mol-1,均为潜在的抗肿瘤药物.
Cu（Ⅱ） complex derived from 8-hydroxyquinoline-2-carboxaldehyde-（benzoyl）hydrazone（2a） and Cu（Ⅱ） complex derived from 8-hydroxyquinoline-2-carboxaldehyde-（p-hydroxybenzoyl）hydrazone（2b） were synthesized and characterized,respectively.The interactions of complexes 2a and 2b with DNA were studied by viscosity titration,Ultraviolet-visible（UV-vis） spectroscopy and fluorescence spectroscopy.The experimental results indicated that both of the complexes 2a and 2b are good intercalators for DNA,and the binding constants are 1.162×10^6 L·mol^-1 and 6.934×10^6 L·mol^-1,respectively,and they may be used as potential antitumor drugs.
出处
《信阳师范学院学报（自然科学版）》
CAS
2010年第3期450-454,共5页
Journal of Xinyang Normal University(Natural Science Edition)
基金
国家自然科学基金项目(20975046)
