一种新型稠合双环氮杂环丙烷衍生物开环反应研究

The Regioselective Ring Opening Reaction of a New Type Bicyclic Fused Aziridines

以醇为溶剂、微量的浓硫酸为催化剂、稠合双环氮杂环丙烷衍生物为底物,通过亲核取代反应将氮杂三环打开,合成了2个新的开环产物.用IR、^1H NMR、^13C NMR、EIMS、元素分析等手段对新化合物进行了结构表征.该方法操作简单,醇既是溶剂又是亲核试剂,产率较高（78%-83%）.

Bicyclic fused aziridines can generate regioselective ring opening reaction with various alcohols,catalyzed by small amount of concentrated sulfuric acid.Two new ring-opening products were obtained and characterized with IR,^1H NMR,^13C NMR and EIMS.In this reaction,alcohols are not only nucleophiles but also solvents.This method provides several advantages such as high yield（78%～83%）,simple work-up procedure,shorter reaction time,milder conditions.