N-脂肪酰基-O-芳氧乙酰基乙醇胺的合成和生物活性

Synthesis and Bioactivity of N-(Fatty acid)-O-aryloxyacetyl-ethanolamine

N-脂肪酰乙醇胺(NAE)是植物体内微量存在的一类高活性脂肪胺.为了改善NAE的溶解性能并进一步提高活性,将芳氧乙酸和NAE结合到同一个分子中,合成了一系列N-脂肪酰基-O-芳氧乙酰基乙醇胺,并测试了生物活性.生物活性结果表明大部分目标化合物促进油菜下胚轴伸长的活性优于母体化合物.苯环上含取代基的衍生物的活性优于无取代基的衍生物,其中苯环上有氯取代的化合物活性与传统的植物生长调节剂2,4-二氯苯氧乙酸相当.

N-Fatty acyl ethanolamine （NAE）, a minor, endogenous constituent in plant, is a kind of fatty amines with high bioactivity. To make up for its solubility deficiency and improve its bioactivity, this paper combined aryloxyacetic acids and NAE into the same molecule and prepared a series of N-（fatty acid）-O-aryloxyacetyl-ethanolamines and tested their bioactivities. Comparing with the mother compound, most title compounds have better bioactivities for stimulating the hypocotyls elongation of rape. The bioactivities of title compounds bearing substituent benzene ring are better than that of those with unsubstituted benzene ring. Especially the chloro-substituted benzene derivatives have the comparable activities with the conventional plant growth regulator 2,4-dichlorophenoxyacetic acid.