新型吡咯类衍生物的合成

Synthesis of Pyrrole Derivatives

2,5-己二酮和胺(氨基硫脲、硫脲、苯胺、氨基酸)经过Paal-Knorr反应合成6个2,5-二甲基-N-取代吡咯衍生物;分别以新合成的N-吡咯甘氨酸、N-苯基吡咯化合物为原料,进行酯化反应和Mannich,Friedel-Craft反应,合成3个N-(2,5-二甲基吡咯)甘氨酸酯类化合物和2个N-苯基-2,5-二甲基吡咯衍生物.所有化合物都通过IR,1HNMR,13CNMR,HRMS波谱方法对其结构进行了确证.

Acetonylacetone was treated with amine （aminothiourea, thiourea, aniline, amino acid） to give six 2,5-dimethyl-N-substitute derivatives by Paal-Knorr reaction. Using the new N-pyrrole glycin and N-phenyl pyrrole compounds as materials, three N-（2,5-dimethyl pyrrole） glycin esters and two N-phenyl-2,5-dimethyl pyrrole derivatives were obtained via esterification reaction and Mannich, Friedel-Craft reactions, respectively. The structures of all the compounds were confirmed by IR, 1H NMR, 13C NMR and HRMS spectra.