透明质酸及其相关蛋白与大鼠肝纤维化的关系

Relationship between levels of hyaluronan and hyaluronan-associated proteins and liver fibrosis of rats

目的：探讨血清透明质酸（HA）及其相关蛋白（SHAP-HA）水平与肝纤维化间的关系.方法：建立实验性肝纤维化动物模型,检测血清HA、SHAP-HA、谷-丙转氨酶（ALT）、谷-草转氨酶（AST）、白蛋白（ALB）,观察大鼠肝组织病理变化.结果：随着肝纤维化程度的加重,血清HA、SHAP-HA表达量均增加,与ALT、AST呈正相关,差异具有统计学意义.结论：实验性肝纤维化过程中HA、SHAP-HA表达水平不仅与肝组织的炎症坏死程度有关,而且与纤维化过程关系密切,HA、SHAP-HA可作为肝纤维化评估指标之一.

Objective： To investigate the relationship between fibrosis pathology and the levels of hyaluronan （HA） and hya- luronan-associated proteins （SHAP-HA） in serum. Methods： Wistar rats were used to establish the experimental model. The levels of serum HA, SHAP-HA, AST, ALT and ALE, and liver homogenate hydroproline were detected. Results： The HA and SHAP-HA levels of serum were significantly increased compared with normal serum. Positive correlations was found among HA, SHAP-HA, ALT and AST with fibrosis progress. Conclusion： Serum HA and SHAP-HA may be useful as an fibrosis marker, the levels of which may be related more closely in the development of experiment liver fibrosis than in the inflammatory process.