牡荆素对麻醉犬血流动力学及心肌耗氧量的影响

Effects of vitexin on hemodynamics and myocardial oxygen consumption in anesthetized dogs

目的研究牡荆素对麻醉犬血流动力学及心肌耗氧量的影响。方法杂种犬30只,人工呼吸下开胸,给药后观察其心率(HR)、血压(MAP)、心输出量(CO)、冠脉血流量(CBF)、左室压(LVP)及血氧含量。计算冠脉阻力(CVR)和体循环总外周阻力(TPR)等血流动力学指标。采用多普勒超声血流仪测定麻醉犬冠脉流量和心输出量,用血气分析仪测定血氧含量。结果牡荆素可减慢心率和左心室内压,并显著增加麻醉犬冠脉血流量和心输出量,降低总外周血管阻力和冠脉阻力,提高心搏出量、心搏指数及心脏指数。结论牡荆素可显著改善麻醉犬血流动力学参数。

Aim To investigate the effects of vitexin on hemodynamics and myocardial oxygen comsumption in anesthetized dogs.Methods In 30 dogs with artificial ventilation,the changes in parameters at different time were observed,such as heart rate（HR）,mean arterial pressure（MAP）,coronary blood flow（CBF）,cardiac output（CO）,left ventricular pressure（LVP）and blood oxygen content.The hemodynamic parameters,coronary vascular resistance（CVR）,total peripheral resistance（TPR）,stroke volume（SV）,stroke index（SI）,cardiac index（CI）,left ventricle stroke work index（LVWI）and myocardium oxygen consumption index（MOCI）were calculated.Coronary artery blood flow and cardiac output were measured by Doppler flow meter.Blood oxygen content was determined by oximeter.Results Vitexin could significantly decline the HR and LVP,but could not change MAP.Vitexin could significantly increase coronary artery blood flow and cardiac output,reduce cerebral vascular resistance,total peripheral resistance and coronary vascular resistance,increase cardiac index,stroke index,stroke volume and decline myocardium oxygen consumption index.Conclusion Vitexin can improve the parameters of hemodynamics in anesthetized dogs.