早产儿凝血功能障碍诊治体会

Diagnosis and treatment of coagulation dysfunction in preterm infants

目的探讨早产儿凝血功能障碍诊治体会。方法对40例有凝血功能障碍早产儿的诊治进行回顾性分析,总结早期DIC诊断及临床抗凝治疗的体会。结果接受抗凝治疗的40名早产儿中有7例发生DIC,其中6例有出血表现,死亡3例。在DIC早、中期使用肝素（0.44-1 mg·kg^-1·d^-1）,有较好疗效。结论早产儿有凝血指标有异常时可以不等DIC临床表现即考虑给予小剂量肝素和（或）补充凝血因子等治疗,可能可以降低DIC的发生率。

Aim To summarize experiences of diagnosis and treatment of coagulation disorder in premature infants.Method 40 cases with coagulation were retrospectively analyzed.The early diagnosis of DIC and clinical anticoagulant therapy experience were summed up.Results There were 7 cases of DIC,six of whom had haemorrhage,three dead.Earlier treatment with 0.44～1 mg·kg^-1·d^-1heparin showed better therapeutic effects on patients with DIC.Conclusions In premature infants with smaller gestational age and more influential factors,clotting factor and/or low dose heparin therapy could be given when coagulation indexes were abnormal,before typical DIC manifestation appeared.It may reduce the morbidity of DIC.