3％氯化钠鼻腔冲洗治疗急性鼻-鼻窦炎的临床疗效分析

Efficacy of daily 3% saline solution nasal irrigation among patients with acute rhinosinusitis

目的 通过应用3％氯化钠鼻腔冲洗可缓解急性鼻-鼻窦炎症状、改善患者生活质量，为临床提供可行性资料和治疗依据。方法50例急性鼻-鼻窦炎患者随机分为治疗组与对照组，每组25例。治疗组子3％氯化钠250mL鼻腔冲洗，1次／d，共1wk。对照组不予冲洗。两组基础治疗相同，在治疗的d3、d5、d7比较两组胃窦炎功能紊乱指数积分情况。结果两组积分采用统计学成组设计的两样本均数比较的t检验。3次积分结果两组均数均有显著性差异，治疗组明显优于对照组（P〈0．05）。结论急性鼻．鼻窦炎患者进行3％氯化钠鼻腔冲洗，可减轻黏膜水肿、增加黏膜上皮电渗透性和促进纤毛运动，且有抑菌作用，有利于窦口引流通畅，从而改善临床症状，提高患者生活质量和减少药物使用。

Objectives To test whether 3% saline solution nasal irrigation improves sinus symptoms and quality of life in adult subjects with a history of acute rhinosinusitis, and provide feasible data for clinic therapy. Methods Randomized controlled trial. 50 subjects were randomized to experimental （n=25） and contral （n=25） groups. Experimental subjects used nasal irrigation （250mL） daily for a week. The basic treatment of the two groups is the same. The Rhinosinusitis Disability Index （RSDI） scores of the two groups were compared three times, on the third day, the fifth day, and the seventh day respectively. Results Statistical analysis was performed using paired student t test. Statistical significance was accepted when P〈0.05. RSDI scores for experimental subjects improved （P〈0.05） at each time compared with control subjects. Conclusions 3% saline solution decreases the nasal edema, enhances the electrical permeability of the airway epithelial mucosa, improves the mucus ciliary beat, and has antibacterial effect. Therefore, daily 3% saline solution nasal irrigation makes the sinuses unobstacled, improves sinus-related quality of life, decreases symptoms, and decreases medication use in patients with acute rhinosinusitis.