摘要
NADH氧化酶作为一类催化NADH和氧气进行氧化反应的酶类,不仅在微生物氧化应激反应中起重要的生理作用,而且是人工调控微生物代谢流向研究中的调控热点;另外,它在氧化态辅酶NAD+再生方面表现出巨大的应用潜力.作者综述了NADH氧化酶的分类和结构、反应机制、分离纯化及应用进展.
As an enzyme for catalyzing the oxidation reaction of NADH and oxygen, NADH oxidase not only plays an important physiological role in microbial oxidative stress response, but also is the hot spot in the study of artificial regulation of microbial metabolic flux. Furthermore, NADN oxidase has great potential in the NAD regeneration. In this paper, we summarized the classification, structure, reaction mechanism, separation and purification and application progress of NADH oxidase.
出处
《河南工业大学学报(自然科学版)》
CAS
北大核心
2010年第4期80-88,共9页
Journal of Henan University of Technology:Natural Science Edition
基金
河南工业大学校引进人才基金项目(2006BS003)
关键词
NADH氧化酶
氧化应激
辅酶再生
代谢调控
NADH oxidase
oxidative stress
coenzyme regeneration
metabolism regulation