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山西汉族人群肾上腺素β_2受体基因多态性与冠心病的相关性研究 被引量：3

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摘要 目的研究山西汉族人群肾上腺素β2受体基因(ADRB2)单核苷酸多态性(SNP)与冠心病的相关性。方法从山西医科大学第二医院选取经冠状动脉造影证实为冠心病的患者428例和与之匹配的经冠状动脉造影证实无冠心病的对照组397例。并记录分析所有研究对象的病史、体格检查等临床资料及其他流行病学资料,采取连接酶检测法检测各组ADRB2基因rs1042713位点A/G基因型并统计各组的基因型频率。结果冠心病组rs1 0 4 2 7 1 3位点A等位基因型频率显著低于对照组(4 5.8%vs5 6.7%,P=0.002,OR=1.548),差异有统计学意义。结论 ADRB2基因rs1042713位点A/G多态性与冠心病的发病密切相关,其中A等位基因可能是山西汉族人群冠心病的保护因素之一。
作者 贾立昕 李俊男 边云飞 刘改珍 肖传实
机构地区 山西医科大学第二医院
出处 《中西医结合心脑血管病杂志》 2010年第8期911-912,共2页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
关键词 肾上腺素能β2受体 ADRB2基因 基因多态性 冠心病
分类号 R541.4 [医药卫生—心血管疾病] R256.2 [医药卫生—中医内科学]
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参考文献12

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同被引文献33

  • 1魏文婷,张红璇,薛凌,黄德仪.心房颤动患者β_2肾上腺素能受体基因多态性与心肌纤维化[J].岭南心血管病杂志,2009,15(6):430-433. 被引量：1
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  • 9Australia and New Zealand Multiple Sclerosis Genetics Consortium(ANZgene). Genome - wide association study identifies new mul-tiple sclerosis susceptibility loci on chromosomes 12 and 20 [ J ].Nat Genet, 2009 , 41(7) : 824 -828.
  • 10HARADA K, MIYAMOTO Y, MORISAKI H, et al. A novelThr56Met mutation of the autosomal recessive hypercholesterolemiagene associated with hypercholesterolemia [ J ]. J AtherosclerThromb, 2010,17(2) : 131 -140.

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中西医结合心脑血管病杂志
2010年 第8期

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