抑肝散对记忆障碍模型小鼠学习记忆能力的影响

Effect of YGS on learning and memory function of the memory disorder mice

目的观察抑肝散对血管性痴呆的核心症状(学习记忆能力减退)的改善作用。方法以东莨菪碱、亚硝酸钠乙醇分别造成不同类型的小鼠记忆障碍模型,用跳台法观察抑肝散对这些记忆障碍模型小鼠的作用。结果抑肝散明显对抗东莨菪碱、亚硝酸钠和30%乙醇等化学物质诱导的小鼠学习记忆障碍,对学习记忆的三个基本神经活动过程均有明显改善作用。结论抑肝散对不同记忆障碍模型小鼠学习记忆能力具有不同程度的改善作用。

Objective To study the effect of YGS on learning and memory function of the memory disorder mice. Methods By step down test we observed the effect of YGS on learning and memory function of scopolamine-induced mice, sodium nitrite-induced mice and ethanol-induced mice. Results It was found that YGS can obviously improve the learning and memory ability of the model mice mentioned previously. Conclusion Yigangsan can improve the learning and memory ability of the memory disorder mice.