基因芯片技术在中药抗肿瘤机制研究中的应用

The Application of Microarray in Anti-tumor Mechanism Research of Traditional Chinese Medicine

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摘要传统新药开发模式愈发艰难,中药及植物药已经成为新药开发的重点。我国是中药的发源地,有效开发中药是提高我国新药研发能力的重要途径,基因芯片技术与传统中药研究的结合有力地促进了中药理论的现代化。本文回顾了近年应用基因芯片技术探索中药抗肿瘤机制方面的研究进展,期望这一技术能促进中药的开发。 Traditional drug development model has become more difficult, traditional Chinese medicine and herbal medicine has become the focus of drug development. China is the birthplace of traditional Chinese medicine, effectively development of Chinese medicine is an important way in improving research capacity of new medicine in our country. The combination of microarray technology and traditional Chinese medicine research can enhance the modernization of the theory of Chinese medicine. The author reviews the recent progress in research of anti-tumor mechanism of traditional Chinese medicine with microarray, hope this technology can improve the development of Chinese medicine.

作者张松波段娟尚云峰

机构地区岳阳职业技术学院湖南省血防所附属湘岳医院

出处《岳阳职业技术学院学报》 2010年第4期98-100,共3页 Journal of Yueyang Vocational and Technical College

关键词基因芯片中药肿瘤 microarray traditional Chinese medicine tumor

分类号 R282 [医药卫生—中药学]

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参考文献3

1邹明瑾,杨美香,郭文静,闫实,曲迅.基因芯片技术在研究中药分子作用机制中的应用[J].山东大学学报（医学版）,2005,43(7):653-656. 被引量：8
2王建军,李宝伟,成军,刘妍,徐志强,杨倩,纪冬,党晓燕,王春花.表达谱基因芯片技术研究甘草甜素上调白介素-18基因的表达[J].世界华人消化杂志,2004,12(4):855-858. 被引量：10
3Ning-Sun Yang,Lie-Fen Shyur,Chih-Huai Chen,Sheng-Yang Wang,Chi-Meng Tzeng. Medicinal herb extract and a single-compound drug confer similar complex pharmacogenomic activities in MCF-7 cells[J] 2004,Journal of Biomedical Science(3):418～422

二级参考文献27

1[1]Khaksa G, Zolfaghari ME, Dehpour AR, Samadian T. Anti-inflammatory and anti- nociceptive activity of disodium glycyrrhetinic acid hemiphthalate. Planta Med 1996;62:326-328
2[2]Kimura M, Watanabe H, Abo T. Selective activation of extrathymic Tcells in the liver by glycyrrhizin. Biotherapy 1992;5:167-176
3[3]Homma M, Oka K, Ikeshima K, Takahashi N, Niitsuma T,Fukuda T, Itoh H. Different effects of traditional Chinese medicines containing similar herbalconstituents on prednisolone pharmacokinetics. J Pharm Pharmacol 1995;47:687-692
4[4]Zhang YH, Isobe K, Nagase F, Lwin T, Kato M, Hamaguchi M, Yokochi T, Nakashima I. Glycyrrhizin as a promoter of the late signal transduction for interleukin-2 production by splenic lymphocytes. Immunology 1993;79:528-534
5[5]Zhang YH, Kato M, Isobe K, Hamaguchi M, Yokochi T,Nakashima I. Dissociated control by glycyrrhizin of proliferation and IL-2 production ofmurine thymocytes. Cell Immunol 1995;162:97-104
6[6]Jeong HG, You HJ, Park SJ, Moon AR, Chung YC, Kang SK,Chun HK. Hepatoprotective effects of 18beta-glycyrrhetinic acid on carbon tetrachloride-induced liver injury: inhibition of cytochrome P450 2E1 expression. Pharmacol Res 2002;46:221-227
7[7]Tanahashi T, Mune T, Morita H, Tanahashi H, Isomura Y,Suwa T, Daido H,Gomez-Sanchez CE, Yasuda K. Glycyrrhizic acid suppresses type 2 11 beta-hydroxysteroid dehydrogenase exporession in vivo. J Steroid Biochem Mol Biol 2002;80:441-447
8[9]Zheng QZ, Lou YJ. Pathologic characteristics of immunologic injury in primary cultured rat hepatocytes and protective effect of glycyrrhizin in vitro. Acta Pharmacol Sin 2003;24:771-777
9[10]Shimoyama Y, Sakamoto R, Akaboshi T, Tanaka M, Ohtsuki K.Characterization of secretory type IIA phospholipase A2(sPLA2-ⅡA) as a glycyrrhizin (GL)-binding protein and the GLinduced inhibition of the CK-Ⅱ-mediated stimulation of sPLA2-ⅡA activity in vitro. Biol Pharm Bull 2001;24:1004-1008
10[11]Miyaji C, Miyakawa R, Watanabe H, Kawamura H, Abo T.Mechanisms underlying the activation of cytotoxic function mediated by hepatic lymphocytes following the administration of glycyrrhizin. Int Immunopharmacol 2002;2:1079-1086