绒毛膜促性腺激素治疗儿童隐睾症172例临床疗效分析

Clinical analysis of human chorionic gonadotropin treatment for 172 cases of cryptorchism in children

目的观察绒毛膜促性腺激素治疗儿童隐睾症的临床有效性。方法采用绒毛膜促性腺激素（HCG）治疗172例隐睾症儿童,通过对年龄、隐睾单双侧和隐睾所在部位进行分层分析,临床评价治疗的有效性。结果应用HCG治疗双侧隐睾的疗效比单侧好,有效率分别为83.3%和51.5%,差异有统计学意义（P〈0.05）;生后3-5岁这个年龄段治疗效果是较好的,有效率达69.2%,与另外两个年龄段的治疗有效率相比,差异有统计学意义（P〈0.05）;低位隐睾包括腹股沟管内和外环口以外,有效率分别为58.5%和66.3%,而高位隐睾有效率仅为8%,三者差异有统计学意义（P〈0.05）。结论对于3-5岁之间、双侧和低位隐睾症的患儿选用HCG治疗有效,但对于雄激素受体数量和功能异常的患儿疗效差,应行手术治疗。

Objective To observe clinical analysis of huaman chorionic gonadotropin treatment for cryptorchism in children.Methods One hundred seventy two cases of ctyptrchism in children recieved huaman chorionic gonadotropin treatment.Stratified analysis including age,unilateral or bilateral cryptorchidism and site was adopted to evaluate the effectiveness of clinical treatment.Results The effective rates of bilateral cryptorchidism treated with HCG was 83.3% and that of unilateral cryptorchidism was 51.5%,there was significant difference between the two rates.（P〈0.05）.HCG for children with cryptorchidism between the ages of three and five had good effective rate reached to 69.2%.The effective rate were 58.5% and 66.3% for cryptorchidism of the inguinal canal and below annulus inguinalis extemalis respectively,while in high cryptorchidism group the effective rate only was 8%,there was significant difference among the three rates.（P〈0.05）.Conclusion HCG is effective in treating bilateral or low ctyptrchism in children aged 3~5 years old.