中西医结合治疗中期糖尿病肾病的临床疗效观察

Clinical efficacy of combined Chinese and western medicine treatment of the medium-term diabetic nephropathy

目的探讨中药联合厄贝沙坦治疗中期糖尿病肾病的临床疗效。方法 43例入选患者,随机分为两组,治疗组与对照组均采取相同的基础疗法,治疗组在对照组基础治疗的基础上采用补中益气汤合六味地黄丸加减,治疗8周。观察两组治疗前、后症状、体征的变化情况,以及检测血清肌酐(Scr)、肌酐清除率(Ccr)以及24h尿蛋白总量。结果①治疗组总有效率达到100%,与对照组总有效率85%分别相比,有明显差异,中西医结合治疗临床疗效明显优于单纯西医治疗(P<0.05)。②治疗组与对照组治疗后相比,Scr、24h尿白蛋白定量分别降低与Ccr上升也有明显差异(P<0.05),表明治疗组在改善糖尿病肾病患者的Scr、Ccr、24h尿微量白蛋白量方面,与对照组相比有明显的优势。结论中药联合厄贝沙坦治疗中期糖尿病肾病的临床疗效明显优越于单用西药效果,值得临床推广。

Objective To explore the clinical effect of medium-term diabetic nephropathy treating with Irbesartan and traditional Chinese medicine.Methods 43 cases selected were randomly divided into two groups,treatment group and control group are taking the same basic therapy,the treatment group in the control group on the basis of basic treatment,use of Bu Zhong Yi Qi Tang and Liu Wei Di Huang Pill,treatment for 8 weeks.Before and after the treatment,observed two groups symptoms and signs of changes,as well as serum creatinine（Scr）,creatinine clearance rate（Ccr） and 24h urine total protein.Results ①The treatment group,the total efficiency of 100% compared with the control group,the total efficiency of 85%,respectively,compared with significant difference between Chinese and Western medicine with the clinical efficacy of the treatment is better than Western medicine treatment alone（P〈0.05）.②The treatment group compared with the control group after treatment,Scr,24h urinary albumin decreased quantity and there are significant differences in Ccr increased（P〈0.05）,showed that the treatment group in improving diabetic nephropathy in patients with Scr、Ccr、24h urinary albumin volume connection,compared with the control group had an obvious advantage.Conclusion The medium-term Diabetic nephropathy treating with Irbesartan combined traditional Chinese medicine has a significantly clinical effect,and superior to western medicine alone effect,it′s worthy to be popularized.