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TNFSF15基因与克罗恩病研究进展 被引量：2

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摘要 胃肠道炎症性肠病(IBD)包括克罗恩病(CD)和溃疡性结肠炎(UC)。近年来对于CD基因易感性的研究成为热点。肿瘤坏死因子超家族成员15(TNFSF15)是新发现的CD的易感基因之一,其蛋白产物TL1A与特异性受体DR3结合可诱导NF-κB的激活,促使细胞凋亡,也能加强Th1和Th17细胞的功能,在免疫调节及炎性反应中具有重要的作用。
作者 张婷 夏敏
机构地区 南京医科大学附属无锡人民医院消化内科
出处 《国际消化病杂志》 CAS 2010年第4期206-209,共4页 International Journal of Digestive Diseases
关键词 肿瘤坏死超家族成员15 克罗恩病 基因易感性 肿瘤坏死因子样配体1A
分类号 R574 [医药卫生—消化系统]
  • 相关文献

参考文献25

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  • 3Hou W,Medynski D,Wu S,et al.VEGI-192,a new isoform of TNFSF15,specifically eliminates tumor vascular endothelial cells and suppresses tumor growth.Clin Cancer Res,2005,11:5595-5602.
  • 4Migone TS,Zhang J,Luo X,et al.TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator.Immunity,2002,16:479-492.
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二级参考文献14

  • 1周军,汪建平,兰平,吴小剑,黄美近,宋新明.结肠抗原特异性T细胞克隆回输治疗大鼠溃疡性结肠炎的研究[J].中华实验外科杂志,2004,21(10):1206-1208. 被引量：14
  • 2汪建平,兰平.结直肠外科临床与基础研究展望[J].中华实验外科杂志,2006,23(7):776-778. 被引量：3
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  • 8Migone TS,Zhang J,Luo X,et al. TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. Immunity, 2002,16:479-492.
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共引文献1

同被引文献25

  • 1刘文斌,吕愈敏,金珠,杨雪玲.钙卫蛋白在溃疡性结肠炎患者结肠黏膜及粪便中的表达及临床意义[J].北京大学学报（医学版）,2005,37(2):179-182. 被引量：17
  • 2Hus H, Viney JL. The tale of TL1A inflammat-ion [ J ]. Muco-sal- Immunol,2011,4(4) :368 - 370.
  • 3Meylan F, Richard AC, Siegel RM. TL1A and DR3, a TNF family ligand-receptor pair that promotes lymphocyte costimulation muco- sal hyperplasia and autoimmune inflammation [ J ]. Immunol Rev, 2011,244(1) :188 - 196.
  • 4BayryJ. Immunology : TL1A in inflammatory network in autoimmune diseases [ J ]. Nat Rev Rheumatol,2010,6 (2) :67 - 68.
  • 5Bamias G, Martin C, Marini M, et al. Expressi-on, localization, and functional activity of TL1 A, a novel Thl-polarizing cytokine in in- flammatory bowel disease [ J]. J Immunol, 2003,171 ( 9 ) : 4868 - 4874.
  • 6Sucher R, Fischler K, Oberhuber R, et al. IDO and regulatory T cell support are critical for cytotoxic T lymphocyte-associated Ag- 4Ig-mediated long-term solid organ allograft survival[ J ]. J Immu- nol,2012,188(1) :37 -46.
  • 7Gotoh A, Hamada Y, Shiobara N, et al. Skew in T cell receptor us- age with poluclonal expansion in lesions of oral lichen planus with- out hepatitis Cvirus infection [ J ]. Clin Exp Immunol, 2008,154 (2) :192 -201.
  • 8Porter SR,Kirby A, Olaen I,et al. Immunol-ogic aspects of dermal and oral lichenplanus: a review [ J ]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 1997,83 (3) :358 - 366.
  • 9Khan A, Farah CS, Savage NW, et al. Thlcytokines in oral lichen planus [J]. J Oral Pathol Med,2003,32(2) :77 -83.
  • 10Zhou G,Xia K, du GF, et al. Activation of nuclear factor-kappa B correlates with tumor necrosis factor-alpha in oral lichen planus :a clinicopathologic study in atrophic-erosive and reticular form [ J ]. J Oral Pathol Med ,2009,38 ( 7 ) :559 - 564.

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国际消化病杂志
2010年 第4期

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