曲灵双葛汤治疗酒精性脂肪肝的临床研究

Clincal study of Quling Shuangge decoction on alcoholic fatty liver

目的评价曲灵双葛汤治疗酒精性脂肪肝的临床疗效。方法选择酒精性脂肪肝78例,按1∶1的比例随机分为治疗组39例,对照组39例。对照组采用常规保肝治疗,治疗组在常规治疗的基础上加用曲灵双葛汤150 mL/次,2次/d,60 d为1个疗程。对比观察2组患者症状、体征变化以及肝功能、血脂水平。治疗前后进行B超检查。结果治疗结束后,治疗组症状、体征均明显改善。胆固醇、三酰甘油、低密度脂蛋白胆固醇、肝功能正常或接近正常,与对照组比较均有显著性差异(P均<0.05)。结论曲灵双葛汤可以缓解酒精性脂肪肝患者的临床症状及体征,改善肝功能及肝脏影像学变化,降低血脂,临床疗效肯定。

Objective It is to evaluate the curative effect of Quling Shuangge decoction on alcoholic fatty liver.Methods 78 patients with alcoholic fatty liver were chosen and randomly divided into treatment group and control group in 1∶1 ratio.39 patients were in treatment group and treated with Quling Shuangge decoction 150 mL for one time and two times a day for 60 days based on conventional therapy.39 patients were in the control group and treated with conventional therapy.The changes of symptom and signs,the liver function and the level of blood fat were compared and observed.Ultrasound examinations were performed in all patients before and after treatment.Results After treatment,the symptom and signs in treatment were all obviously improved.The levels of TC,TG,LDL-C and liver function were normal or almost reached normal.There was significant difference between the two groups（P〈0.05）.Conclusion Quling Shuangge decoction can release the clinical symptom and signs of the patients with alcoholic fatty liver,improve the liver function and liver iconography changes and lower the blood fat.The clinical curative effect is affirmative.