福辛普利对老年不稳定型心绞痛患者超敏C-反应蛋白的影响

Effects of fosinopril on high-sensitivity C-reactive protein in elderly patients with unstable angina

目的观察老年不稳定型心绞痛患者血清超敏C-反应蛋白(hs-CRP)的浓度变化及福辛普利对其的影响。方法选择不稳定型心绞痛患者65例,入院后抽取空腹静脉血检测hs-CRP。血清hs-CRP>3.0mg/L者46例随机分为常规治疗组与福辛普利组(接受常规治疗+福辛普利5mg,1次/d,口服)。治疗2周后再次抽取空腹静脉血检测hs-CRP。结果 65例老年不稳定型心绞痛患者中血清hs-CRP有不同程度的增高,其中高度风险者(hs-CRP>3.0mg/L)46例,占入选者的70.8%;2组治疗后血清hs-CRP浓度较治疗前均有降低,且差异有统计学意义(P<0.05或P<0.01);福辛普利组较常规治疗组血清hs-CRP浓度降低显著,差异有统计学意义(P<0.05)。结论老年不稳定型心绞痛患者血清hs-CRP浓度不同程度增高,且大部分患者处于高度风险。福辛普利可降低老年不稳定型心绞痛患者血清hs-CRP的水平。

Objective To investigate the effects of fosinopril on the level of serum high-sensitivity C-reactive protein （hs-CRP） in elderly patients with unstable angina pectoris（UAP）. Methods A total of 65 patients with UAP were chosen into this study. The serum hs-CRP was measured after admission. Forty-six patients with hs-CRP 3.0 mg/L were randomly divided into 2 groups, routine therapy group and fosinopril therapy group （receiving routine therapy＋fosinopril 5 mg, qd, oral）. The serum hs-CRP was measured again after 2 weeks. Results The level of serum hs-CRP increased more or less in all of 65 patients with UAP, among which high-risk patients （hs-CRP 3.0 mg/L） were up to 46 cases （70.8%）. The level of serum hs-CRP was significantly decreased in both groups after treatment （P0.05 in routine therapy group; P0.01 in fosinopril therapy group）. Furthermore, the level of serum hs-CRP in fosinopril therapy group was significantly reduced than that in the routine therapy group （P0.05）. Conclusions The level of serum hs-CRP in elderly patients with UAP was increased to some extent, and the majority of them were at high risk. Fosinopril could reduce the level of serum hs-CRP in elderly patients with UAP.