绝经后女性血清胆红素及血脂水平与冠状动脉病变程度的相关性

The effect of serum bilirubin and blood lipid disorder on coronary artery stenosis in postmenopausal patients

目的分析绝经后女性的血清胆红素及血脂水平与冠状动脉狭窄的关系,探讨其预测老年女性冠心病发病的临床意义。方法对116例疑似冠心病的绝经后女性患者行冠脉造影并测定血清胆红素及血脂水平,采用Gensini评分系统衡量冠脉造影结果。依据冠脉造影结果,分为对照组、单支病变组和多支病变组。结果单因素方差分析显示,血清总胆红素、间接胆红素、总胆固醇、甘油三酯、低密度脂蛋白胆固醇在各组间的分布差异具有统计学意义(P<0.01);多元线性回归分析显示,血清总胆红素、直接胆红素与冠状动脉狭窄程度的评分独立相关(其偏相关系数分别为-2.333,P<0.01;-1.234,P<0.05)。结论血清胆红素及血脂代谢紊乱可能参与了绝经后女性冠心病的发生与发展,血清胆红素和血脂的检测对预测评估绝经后女性冠心病有一定的临床价值。

Objective To investigate the relationship between serum bilirubin,blood lipid and coronary artery stenosis in postmenopausal patients,and to discuss the predicative effect of serum bilirubin and blood lipid level on coronary heart disease in aged female.Methods All the 116 CHD suspected postmenopausal patients underwent coronary angiography and detection on serum bilirubin and blood lipid.The results of coronary angiography were analyzed by Gensini scoring system.All patients were divided into three groups according to the coronary angiography result.Results The analysis of one way variance showed that serum total bilirubin（TBil）,indirect bilirubin,total cholesterol,triglyceride,low density lipoprotein cholesterol were distributionally different between groups（P〈0.01）.Multiple linear regression analysis showed that TBil、direct bilirubin had independent association with the Gensini score（partial correlation coefficient：-2.333,P〈0.01;-1.234,P〈0.05）.Conclusions Metabolic disorder on both serum bilirubin and blood lipid may play a role in coronary heart disease developed in postmenopausal female.The combined detection of serum bilirubin and blood lipid may have preditive effect on coronary heart disease diagnosis in postmenopausal patients.