老年患者血浆D-二聚体与临床各因素间相关性研究

Research on the relationship between elevated plasma D-dimer and clinical factors

目的探讨老年患者血浆D-二聚体升高的临床特点及意义。方法依次纳入我院内科住院且血浆D-二聚体升高者503例,正常者112例,并分为老年升高组、非老年升高组和正常对照组。分析3个组的血浆D-二聚体与临床各因素、老年常见疾病间的相关性。结果老年升高组升高的血浆D-二聚体与血浆纤维蛋白降解产物(FDP)、纤维蛋白原(Fig)、血清C反应蛋白(CRP)显著正相关;并与FDP呈线性相关(P=0.000),与Fig有线性相关趋势(P=0.052);各种疾病对其影响大小依次为:静脉血栓、急性心肌梗死、不稳定性型心绞痛。结论老年患者血浆D-二聚体升高有其自身的临床特点及意义,其与静脉血栓性疾病关系最大,其次为动脉粥样硬化性疾病。

Objective To explore the clinical features and significance of the elevated plasma D-dimer in elderly patients.Methods Data of 503 cases with elevated plasma D-dimer and 112 cases with normal plasma D-dimer were collected,patients were hospitalized in the medical department of our hospital.All patients were divided into three groups inclouding the elderly group with elevated plasma D-dimer,non-elderly group with elevated plasma D-dimer,and normal control group with normal plasma Ddimer.Relationships between plasma D-dimer and clinical factors,common diseases in all patients were analyzed.Results In the elderly group with elevated plasma D-dimer,the plasma D-dimer had a significant positive correlation with FDP,Fig,serum C-reactive protein（CRP）;and showed a linear correlation with plasma FDP（P=0.000）and a tendency of linear correlation with plasma Fig（P=0.052）;Its power of impact on various diseases were as follows：venous thrombosis,acute myocardial infarction,unstable angina pectoris.Conclusions In the elderly group,different from non-elderly group,elevated plasma D-dimer was significantly correlated with blood high fibrinogen,fibrinolytic status.and had the firstly strongest relationship to venous thrombosis,secondly atherosclerotic disease.