海洋真菌Nigrospora sphaerica的化学成分(Ⅱ)

Chemical constituents from the marine Nigrospora sphaerica(Ⅱ)

目的对海洋真菌Nigrospora sphaerica中的化学成分进行研究。方法采用硅胶柱色谱、凝胶以及HPLC等方法进行分离纯化,根据理化性质和光谱数据进行结构鉴定。结果分离得到了8个化合物,分别鉴定为柄曲霉素(sterigmatocystin,1)、4-苄基-3-苯基-5氢呋喃酮(4-benzyl-3-phenyl-5H-furan-2-one,2)、异黄光素[7,8-dimethyl,benzo(g)pteridine-2,4(1H,3H)-dione,3]、5,8二羟基-7甲氧基黄酮(5,8-dihydroxy-7-methoxy-2-phenyl,4H-1-benzopyran-4-one,4)、1(2H)-3,4-二氢-4,8二羟基萘[3,4-dihydro-4,8-dihydroxy,1(2H)-naphthalenone,5]、3,5双去氧-5-苯基戊糖酸γ内酯(3,5-dideoxy-5-phenyl-,γ-lactone,pentonic acid,6)、4-羟基苯乙醇乙酯(4-hydroxyphe-nylethyl acetate,7)、1,4-二氧-2,5-二酮-3,6-二苯甲基聚酯[3,6-bis(phenylmethyl)-1,4-dioxane-2,5-dione,8]。结论真菌Nigrospora sphaerica为首次从海洋中分离得到,化合物1-8为首次从该菌中分离得到。

Objective To study chemical constituents from the marine Nigrospora sphaerica.Methods The compounds were isolated by chromatography on silica gel columns LH-20 and HPLC,and identified by their physical-chemical properties and spectral analysis.Results Eight compounds were obtained and identified as sterigmatocystin,（1）,4-benzyl-3-phenyl-5H-furan-2-one（2）,7,8-dimethyl,benzo（g）pteridine-2,4（1H,3H）-dione（3）,5,8-dihydroxy-7-methoxy-2-phenyl,4H-1-benzopyran-4-one（4）,3,4-dihydro-4,8-dihydroxy,1（2H）-naphthalenone（5）,3,5-dideoxy-5-phenyl-,γ-lactone,pentonic acid（6）,4-hydroxyphenylethyl acetate（7）,3,6-bis（phenylmethyl）-1,4-dioxane-2,5-dione（8）,respectively.Conclusions Nigrospora sphaerica was gotten from marine for the first time,compounds 18 were isolated from the marine fungi for the first time.