费菜茎叶的化学成分

Chemical constituents from the stems and leaves of Sedum aizoon L.

目的对费菜(Sedum aizoonL.)茎叶的化学成分进行研究。方法采用硅胶柱色谱?ODS柱色谱、Sephadex LH-20柱色谱和HPLC柱色谱分离纯化,依据理化性质和光谱数据确定化合物的结构。结果从费菜茎叶体积分数为70%的乙醇提取物的乙酸乙酯层中分离得到11个化合物,分别鉴定为:山柰酚(kaempferol,1)、槲皮素(quercetin,2)、杨梅素(myricetin,3)、木樨草素(luteolin,4)、山柰酚-3-O-α-L-鼠李糖苷(kaempferol-3-O-α-L-rhamnosid,5)、草质素-8-O-α-D-来苏糖苷(herbace-tin-8-O-α-D-lyxoside,6)、草质素-8-O-β-D-木糖苷(herbacetin-8-O-β-D-xylopyranoside,7)、对羟基苯酚(1,4-benzenediol,8)、没食子酸(gallic acid,9)、没食子酸甲酯(methyl gallate,10)、β-谷甾醇(β-sitostero,11)。结论化合物4、7、8为首次从该植物中分离得到,化合物5、6为首次从本属植物中得到。

Objective To investigate chemical constituents from the stems and leaves of Sedum aizoon L..Methods The chemical constituents were isolated by various isolation methods（silica gel,ODS,Sephadex LH-20 and HPLC column chromatography）and their structures were elucidated by the analysis of spectral data and chemical properties.Results Eleven compounds were isolated from the constituents of the ethyl acetate-soluble portion of the 70%ethanol extract of the stems and leaves of Sedum aizoon L.and their structures were identified as kaempferol（1）,quercetin（2）,myricetin（3）,luteolin（4）,kaempferol-3-O-α-L-rhamnosid（5）,herbacetin-8-O-α-D-lyxoside（6）,herbacetin-8-O-β-D-xylopyranoside（7）,1,4-benzenediol（8）,gallic acid（9）,methyl gallate（10）β-sitostero（11）.Conclusions 4,7 and 8 are isolated from Sedum aizoon L.for the first time and 5 and 6 are isolated from Sedum for the first time.