太极拳运动对肥胖患者全基因组表达的影响

Influence of Tai chi Chuan on Global Gene Expression of Patients with Obesity

为从分子水平上研究太极拳运动对促进病人健康的良好影响,6名肥胖并高胰岛素血症患者(62.9±4.2岁,3名男性,3名女性)参加了课题的研究。通过一系列分子生物学实验,发现太极拳运动使高胰岛素血症患者体内AMPK活性有恢复正常水平的趋势,且使AMPK三种亚型(1,2和β1)的表达趋于正常,这为生产调节AMPK活性基因药物,并对Ⅱ型糖尿病的靶向治疗提供了思路。同时有氧运动可使组织纤维蛋白溶酶原激活剂(t-PA)、结缔组织激活肽III(CTAP III)以及四连接素(tetranectin)基因表达发生改变,而这些基因表达异常是导致代谢综合症的重要原因,代谢综合症又是导致外周血管疾病以及血栓形成的重要因素,表明有氧运动可有效避免这些疾患的发生。

In order to research TCC＇s （ TCC, （TCC, a kind of Chinese traditional shadow boxing） good effect on patient＇ s health, Six patients with obesity and hyperinsulinemia （62.9 ± 4.2yr of age, including male and female） participated aerobic exercise training, a series molecular experiments were finished. After TCC, the abnormal differentially expressed genes would decrease , the fatty acids oxidation and aerobic oxidation of carbohydrate enhanced, which improved the economy of energy metabolism, and so the lactic acid reduced, muscle glycogen and hepatic glycogen increased, which may prevent the hyperinsulinemia from developing to noninsulin dependent diabetes （NIDD）. TCC made AMPK activity in hyperinsulinemia patients recover to normal level, and made three types of AMPK （1, 2 and β1） express normally, which provide a good idea for producing gene drug to regulate AMPK activity and targeted therapy of NIDD.