脑内血管紧张素及其在延髓对心血管活动的调节

Brain Angiotensin and Its Role in Cardiovascular Regulation in the Ventrolateral Medulla

血管紧张素（angiotensins，ANG）包括ANGⅠ、ANGⅡ、ANGⅢ、ANGⅣ，其受体亚型有AT1、AT2、AT4三种。一般认为，脑内血管紧张素的功能是由ANGⅡ与AT1受体结合完成的，但目前认为，脑内正常心血管功能是由ANG（1—7）与其特异性受体（AT5？）结合完成的；还有人指出，ANCⅢ与ANCⅡ在中枢效应中起着同等重要甚至比ANGⅡ更重要的作用。延髓腹外侧区（ventrolateralmedulla，VLM）是中枢重要的心血管活动的调控区域，在VLM通过氨基酸类神经递质影响心血管活动，并导致某些高血压的发生。

Angiotensins(Ang) include AngⅠ, AngⅡ, AngⅢ, AngⅣ. There are three kinds of agiotensin receptor suhtype AT1, AT2 and AT4. It is widely accepted that the actions of the brain angiotensins are attributable to AngⅡ mediated by AT1 receptors. But now it is established combining Aug(1-7) with the specific receptors(AT5?) modulates cardiovascular function. Other researchers consider AngⅢ is as important as AngⅡ in the central effects or even more. The ventrolateral medulla plays an important role in the cardiovascular control. Angiotensins affect cardiovascular activities through the release of amino acid neurotransmitters in this area, and may be involved in the generation of hypertension.