氯吡格雷联合蚓激酶治疗急性期脑梗死的疗效观察

Clinical observation of effect of clopidogrel combined with iumbrokinace on acute cerebral infarction

目的探讨氯吡格雷联合蚓激酶治疗急性期脑梗死的临床疗效。方法将143例脑梗死患者随机分为治疗组和对照组。比较两组治疗前后的血液流变学实验室指标、神经功能缺损程度评分及疗效。结果治疗组和对照组患者治疗前、后血液流变学各指标间差异均有显著性意义,且两组患者治疗后纤维蛋白原含量、红细胞聚集指数、红细胞变形指数、血浆粘滞度间差异均有显著性(P<0.05)。治疗后7天起治疗组神经功能缺损程度评分较对照组明显减少,28 d后差异更显著(P<0.05)。治疗后28天疗效评定,治疗组总有效率为80.3%,对照组总有效率为69.4%,两组差异有显著性(P<0.05)。结论氯吡格雷联合蚓激酶治疗急性期脑梗死疗效显著,且安全可靠,为急性期脑梗死的治疗提供了选择的机会。

Objective To study the clinical effect of clopidogrel combined with Iumbrokinace on cerebral infarction. Methods 143 cases of acute cerebral infarction were randomly divided into two groups： 71 cases in treatment group were treated with clopidogrel combined with Iumbrokinace, 72 cases in control group were treated with clopidogrel. Hemorheological indexes were checked before and after therapy, The neurological deficit＇scale and curative effect of the two groups were compared. Results Hemorhelogical indexes were significantly different in two groups before and after therapy. In comparison with control group, hemorrhe - ological indexes such as plasma viscosity, fibrinogen concentration of plasma, deformation index of red blood cell （ RBC ） and aggregation index of RBC were significantly different （ P 〈 0.05 ）. The neurological deficit scale in treatment group were significantly lower than those in control group on the 7 th day aftertreatment, and more on the 28th day （ P 〈 O. 05 ）. On the 28th day after treatment, the total effective rate of treatment group and control group was 80.3% and 69.4%. There is obvious difference in two groups of curative effect （ P 〈 0.05 ）. Conclusion Clopidogrel combined with Iumbrokinace is efficient in treating senile celebral infarction just with very slight adverse effects, and provides se- lectable chance in the treatment of cerebral infarction.