期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

脂联素及基因多态性与糖尿病肾病 被引量：1

脂联素及基因多态性与糖尿病肾病
下载PDF
导出
摘要 脂联素是一种新近发现的由脂肪细胞特异性分泌的蛋白,具有调节糖和脂肪代谢、抗炎、抗动脉粥样硬化等作用。人脂联素基因序列中存在着相当数量的等位基因单核苷酸多态性(SNPs),脂联素基因的SNPs与糖尿病肾病遗传易感性相关,这可能为糖尿病肾病的早期诊断和基因治疗提供了新的手段。 Adiponectin is a newly discovered special protein secreted by adipocytes.with the regulation of glucose and lipid metabolism.anti-inflammatory,anti-atherosclerosis effects.A large number of alleles single nucleotide polymorphisms（SNPs）appear in adiponectin gene sequences of people.The SNPs are related to heredity susceptibility of diabetic nephropathy,which are likely to provide a new means for the early diagnosis and gene therapy of diabetic nephropathy.
作者 闵艳 陈军宁
机构地区 桂林医学院附属医院肾内科
出处 《当代医学》 2010年第24期26-27,136,共3页 Contemporary Medicine
关键词 脂联素 单核苷酸多态性(SNPs) 糖尿病 糖尿病肾病 Adiponectin Single nucleotide polymorphisms Diabetes Diabetic nephropathy
分类号 R587.2 [医药卫生—内分泌]
  • 相关文献

参考文献3

二级参考文献20

  • 1董艳,李果,骆天红,吴刚,黄薇,罗敏.脂联素基因多态性与2型糖尿病的关系[J].上海第二医科大学学报,2004,24(12):1001-1003. 被引量：27
  • 2钱雅新,彭文,王浩.糖尿病肾病血清TGF-β_1改变及普伐他汀的治疗作用[J].实用诊断与治疗杂志,2006,20(2):117-119. 被引量：17
  • 3Kumada M,Kihara S,Sumil,s uji S,et a1. Association Of hypo aIJiponectinemia with coronary artery disease in men[J].Arterioscler Thromb Vasc.Biol,2003,23(1):85-89.
  • 4Hadjadi S, Aubert R, Fumeron F, et al. Increased plasma adiponectin concentrations are associated with microanglopathy in type 1 diabetic subjects[J]. Diabetologia, 2005, 48(6) : 1088- 1092.
  • 5Mallamaci F, Zoccali C, Cuzzola F, et al. Adiponectin in essential hypertension[J]. J Nephrol, 2002, 15(5):507-511.
  • 6Goldstein B J, Scalia R. Adiponectin: a novel adipokine linking adipocytes and vascular function[J]. J Clin Endocrinol Metab, 2004, 89(6):2563-2568.
  • 7Fasshauer M, Klein J, Neumann S, et al. Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes[J]. Biochem Biophys Res Commun, 2002, 290(3):1084-1089.
  • 8Arita Y, Kihara S, Ouchl N, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity[J]. Biochem Biophys Res Commun, 1999, 257(1) :79-83.
  • 9Tan K C, Xu A, Chow W S, et al. Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilation[J].J Clin Endocrinol Metab, 2004, 89(2):765-769.
  • 10Hadjadj S, Aubert R, Fumeron F, et al. Increased plasma adiponectin concentrations are associated with microangiopathy in type 1 diabetic subjects[J]. Diabetologia, 2005, 48(6):1088-1092.

共引文献16

同被引文献38

  • 1Hotta K, Funahashi T, Arita Y, et al. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type2diabetic patients. Arterioscler Thromb Vasc Biol[J]. 2000, 20(6): 1595-1599.
  • 2Liu M, Liu F. Transcriptional and post-translational regulation of adiponectin[J]. Biochem J, 2009, 425(1): 41-52.
  • 3Scherer P E, Willians S, Fogliano M, et al. A novel serum protein similar to C 1 q, produced exclusively in adipocytes[J]. J Biol Chem, 1995, 270(45): 26746-26749.
  • 4Arita Y, Kihara S, Ouchi N, et al. Paradoxical decrease of an adipose specific protein, adi-ponectin, in obesity[J]. Biochem Biophys Res Commun, 1999, 257(1): 79-83.
  • 5Heid I M, Henneman P, Hicks A, et al. Clear detection of ADIPOQ locus as the major gene for plasma adiponectin results of European 412-420 genome-wide association analyses including 4659 individuals[J]. Atherosclerosis, 2010, 208(2).
  • 6Yamauchi T, Kamon J, Ito Y, et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects[J] Nature, 2003, 423(6941): 762-769.
  • 7Hug C, Wang J, Ahmad N S, et al. T-cadherin is a receptor for hexamerie and high-molecular-weight forms of Aerp30/ adiponectin[J]. Proc Nalt Acad Sci USA, 2004, 101(28): 10308-10313.
  • 8Takemura Y, Ouchi N, Shibata R, et al. Adiponectin modulates inflammatory reactions via calreticulin receptor- dependent clearance of early apoptotic bodies[J]. J Clin Invest, 2007, 117(2): 375-386.
  • 9Siitonen N, Pulkkinen L, Lindstr6m J, et al. Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study[J]. BMC Med Genet, 2011, 12:5.
  • 10Avery P J, Patel S K, Ibrahim I M, et al. Common variation in the adiponectin gene has an effect on systolic blood pressure[J]. J Hum Hypertens, 2011, 25(12): 719-724.

引证文献1

二级引证文献1

当代医学
2010年 第24期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部