重型颅脑损伤患者早期营养支持的随机对照研究

目的探讨重型颅脑损伤早期营养支持的临床疗效。方法 100例重型颅脑损伤患者随机分为肠内营养组(EN组)和肠外营养组(PN组),每组50例。于伤后36～48h开始经不同途径进行额定热卡和氮量的营养支持,监测各项营养指标、代谢指标及营养支持并发症,计算营养费用。结果 EN与PN均有效地维持了各项营养指标,但PN组代谢指标、营养支持并发症及营养费用均显著高于EN组。结论早期EN与PN均能改善机体的营养状况,EN具有简易安全、方便价廉等优点,PN则能提供更全面的营养。

Objective To explore the clinical therapeutic efficacy of early nutritional support in patients with severe head injury.Methods 100 patients with severe head injury were divided into enteral nutrition group（ENG） and parenteral nutrition group（PNG） at random.Treated after injury 36-48 hours.all the patients received the rationed nitrogen and calorie containing nutritional support via different pathway.At the same time,we had monitored the nutritional indexes.the metabolic indexes.the complications of nutritional support and calculating the nutritional costs during the whole treatment.Results The nutritional indexes were effectively maintained in both ENG and PNG.but the metabolic indexes.the complications of nutritional support and the nutritional costs of the PNG rose more obviously than those of the ENG.Conclusion Early EN and PN nutritional support can improve the nutritional status of the body.EN has much benefit,including safety,convenience and low cost.PN can apply comprehensive nutrition.[